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• W895595844 abstract "Chapter 12 focuses on the medicinal chemistry aspects of biological approaches to cancer therapy—that is, the use of living organisms or substances derived from living organisms (including synthetic versions of such substances) to treat cancer. Most of the targets and mechanisms included in this chapter are related to immune responses. Although several examples of targeted monoclonal antibodies and gene therapies, which are a significant part of these biological therapies, have been mentioned in previous chapters, Chapter 12 gives a general overview of their types and significance, including several additional targets and applications. Modulators of cancer immunotherapy, which are expected to afford successful cancer treatments, are also discussed, including immunotoxins, vaccines, cancer-killing microorganisms, and adoptive T-cell transfer. Also included in this chapter is a discussion of the different types and strategies of gene therapy and the use of oncolytic viruses, as well as the design of antisense oligonucleotides and their types, with examples given of antisense oligonucleotides that have entered clinical trials. Some of these treatments are also mentioned throughout the book in the context of their respective targets. Finally, Chapter 12 discusses a variety of natural and genetically modified nonpathogenic bacterial species that are being explored as potential antitumor agents, as well as the use of bacterial toxins." @default.
• W895595844 created "2016-06-24" @default.
• W895595844 creator A5037562938 @default.
• W895595844 creator A5045906591 @default.
• W895595844 date "2015-01-01" @default.
• W895595844 modified "2023-10-14" @default.
• W895595844 title "Biological Therapy of Cancer" @default.
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