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- W89623162 abstract "Abstract 4-Amino-N10-methyl-pteroylglutamic acid in the usual treatment dosage caused a slight leukopenia, but no change in the differential count of normal mice. However, in animals with the Ak 4 strain of transplanted leukemia, such dosage caused prolongation of survival time, held the total leukocyte count at approximately normal levels, decreased the percentage of abnormal cells, and caused a marked delay in the appearance of leukemic infiltrations in liver, spleen, lymph nodes, kidney and bone marrow. Less than twenty hours after administration, a single massive dose of this drug caused a fall in the total leukocyte count of mice with advanced Ak 4 leukemia." @default.
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- W89623162 date "1950-02-01" @default.
- W89623162 modified "2023-10-03" @default.
- W89623162 title "THE EFFECTS OF 4-AMINO-N10-METHYL-PTEROYLGLUTAMIC ACID ON THE LEUKOCYTES OF THE NORMAL AND LEUKEMIC MOUSE" @default.
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- W89623162 doi "https://doi.org/10.1182/blood.v5.2.167.167" @default.
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