FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W896564621> ?p ?o ?g. }

• W896564621 endingPage "9" @default.
• W896564621 startingPage "1" @default.
• W896564621 abstract "We aimed to investigate the impact of the epigenome in inducting fetal alcohol spectrum disorder (FASD) phenotypes in Japanese rice fish embryogenesis. One of the significant events in epigenome is DNA methylation which is catalyzed by DNA methyltransferase (DNMT) enzymes. We analyzed DNMT enzyme mRNA expressions in Japanese rice fish development starting from fertilized eggs to hatching and also in embryos exposed for first 48h of development either to ethanol (300mM) or to 5-azacytidine (5-azaC; 2mM), an inhibitor of DNMT enzyme activity. As observed in FASD phenotypes, 5-azaC exposure was able to induce microcephaly and craniofacial cartilage deformities in Japanese rice fish. Moreover, we have observed that expression of DNMTs (dnmt1, dnmt3aa, and dnmt3bb.1) are developmentally regulated; high mRNA copies were found in early stages (1-2day-post-fertilization, dpf), followed by gradual reduction until hatched. In ethanol-treated embryos, compared to controls, dnmt1 mRNA is in reduced level in 2dpf and in enhanced level in 6dpf embryos. While dnmt3aa and 3bb.1 remained unaltered. In contrast, embryos exposed to 5-azaC have an enhanced level of dnmt1 and dnmt3bb.1 mRNAs both in 2 and 6dpf embryos while dnmt3aa is enhanced only in 6dpf embryos. Moreover, endocannabinoid receptor 1a (cnr1a) mRNA which was found to be reduced by ethanol remained unaltered and cnr1b and cnr2 mRNAs, which were remained unaltered by ethanol, were increased significantly by 5-azaC in 6dpf embryos. This study indicates that the craniofacial defects observed in FASD phenotypes are the results of dysregulations in DNMT expressions." @default.
• W896564621 created "2016-06-24" @default.
• W896564621 creator A5022837135 @default.
• W896564621 creator A5076509871 @default.
• W896564621 date "2015-10-01" @default.
• W896564621 modified "2023-10-10" @default.
• W896564621 title "DNA methyltransferase expressions in Japanese rice fish (Oryzias latipes) embryogenesis is developmentally regulated and modulated by ethanol and 5-azacytidine" @default.
• W896564621 cites W1499598203 @default.
• W896564621 cites W1963498389 @default.
• W896564621 cites W1963675298 @default.
• W896564621 cites W1969452238 @default.
• W896564621 cites W1976798783 @default.
• W896564621 cites W1978882696 @default.
• W896564621 cites W1987580795 @default.
• W896564621 cites W1992820158 @default.
• W896564621 cites W1997184565 @default.
• W896564621 cites W1997266531 @default.
• W896564621 cites W1997860363 @default.
• W896564621 cites W1997940605 @default.
• W896564621 cites W2000021700 @default.
• W896564621 cites W2002129512 @default.
• W896564621 cites W2002261580 @default.
• W896564621 cites W2006077490 @default.
• W896564621 cites W2008563981 @default.
• W896564621 cites W2027981586 @default.
• W896564621 cites W2034169870 @default.
• W896564621 cites W2034602099 @default.
• W896564621 cites W2035697450 @default.
• W896564621 cites W2036078075 @default.
• W896564621 cites W2040017882 @default.
• W896564621 cites W2041884054 @default.
• W896564621 cites W2044567499 @default.
• W896564621 cites W2053708409 @default.
• W896564621 cites W2058854128 @default.
• W896564621 cites W2060446375 @default.
• W896564621 cites W2061463822 @default.
• W896564621 cites W2075276600 @default.
• W896564621 cites W2078146373 @default.
• W896564621 cites W2085207628 @default.
• W896564621 cites W2086093927 @default.
• W896564621 cites W2088358849 @default.
• W896564621 cites W2090450153 @default.
• W896564621 cites W2095013890 @default.
• W896564621 cites W2095279623 @default.
• W896564621 cites W2106670153 @default.
• W896564621 cites W2115901664 @default.
• W896564621 cites W2118513045 @default.
• W896564621 cites W2125104163 @default.
• W896564621 cites W2129754994 @default.
• W896564621 cites W2144720261 @default.
• W896564621 cites W2146481807 @default.
• W896564621 cites W2150636510 @default.
• W896564621 cites W2151172630 @default.
• W896564621 cites W2152313931 @default.
• W896564621 cites W2152948116 @default.
• W896564621 cites W2156839509 @default.
• W896564621 cites W2157684747 @default.
• W896564621 cites W2171519735 @default.
• W896564621 cites W2275293999 @default.
• W896564621 cites W4210997484 @default.
• W896564621 cites W4297845902 @default.
• W896564621 doi "https://doi.org/10.1016/j.cbpc.2015.07.002" @default.
• W896564621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26183885" @default.
• W896564621 hasPublicationYear "2015" @default.
• W896564621 type Work @default.
• W896564621 sameAs 896564621 @default.
• W896564621 citedByCount "21" @default.
• W896564621 countsByYear W8965646212016 @default.
• W896564621 countsByYear W8965646212017 @default.
• W896564621 countsByYear W8965646212018 @default.
• W896564621 countsByYear W8965646212019 @default.
• W896564621 countsByYear W8965646212020 @default.
• W896564621 countsByYear W8965646212021 @default.
• W896564621 countsByYear W8965646212022 @default.
• W896564621 countsByYear W8965646212023 @default.
• W896564621 crossrefType "journal-article" @default.
• W896564621 hasAuthorship W896564621A5022837135 @default.
• W896564621 hasAuthorship W896564621A5076509871 @default.
• W896564621 hasConcept C104317684 @default.
• W896564621 hasConcept C150194340 @default.
• W896564621 hasConcept C153911025 @default.
• W896564621 hasConcept C16685009 @default.
• W896564621 hasConcept C175211621 @default.
• W896564621 hasConcept C190727270 @default.
• W896564621 hasConcept C196843134 @default.
• W896564621 hasConcept C2777289358 @default.
• W896564621 hasConcept C2779979206 @default.
• W896564621 hasConcept C33288867 @default.
• W896564621 hasConcept C54355233 @default.
• W896564621 hasConcept C552990157 @default.
• W896564621 hasConcept C71924100 @default.
• W896564621 hasConcept C86803240 @default.
• W896564621 hasConcept C87073359 @default.
• W896564621 hasConcept C91965660 @default.
• W896564621 hasConcept C95444343 @default.
• W896564621 hasConceptScore W896564621C104317684 @default.
• W896564621 hasConceptScore W896564621C150194340 @default.
• W896564621 hasConceptScore W896564621C153911025 @default.

• next