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- W8966006 abstract "Immunological aspects of the nicotinic acetylcholine receptor (AChR) are of special interest mainly due to the involvement of this receptor as an autoantigen in myasthenia gravis. Immunization of animals with purified AChR, results in an immune response against the injected as well as self AChR; this immune response is accompanied by muscular weakness designated experimental autoimmune myasthenia gravis (EAMG). Molecular dissection and immunological analysis of AChR were attempted in order to identify the molecular entities which are responsible for the cholinergic binding activity and/or the pathologic myasthenic activity of the receptor molecule. Monoclonal anti-AChR antibodies directed against defined determinants of AChR were obtained by hybridization of mouse antibody producing cells with a mouse myeloma line. One of the monoclonal antibody lines which were specific to conformational antigenic determinants in AChR, was shown to be directed against the cholinergic binding site." @default.
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- W8966006 date "1982-01-01" @default.
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- W8966006 title "Acetylcholine Receptor Antibodies" @default.
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- W8966006 doi "https://doi.org/10.1016/b978-0-08-028022-6.50023-0" @default.
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