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- W896613488 abstract "目的 研究蛙皮素对正常胃黏膜上皮细胞的促生长作用及其与细胞周期调控因子之间的关系。方法 应用人胃黏膜上皮永生细胞株GES-1，经蛙皮素及受体拮抗剂不同处理后，以MTT为指标研究对细胞增殖的影响；流式细胞仪观察对细胞cyclin D1表达的影响；利用Western印迹和增强化学发光法观察CDK4蛋白表达的变化；利用Sepharose微珠免疫沉淀方法检测对CDK4活性的影响。结果 蛙皮素在浓度为10-7mol/L时对GES-1细胞有明显的促生长作用，对cyclin D1表达有促进作用；蛙皮素受体拮抗剂均抑制这些作用；同时还发现蛙皮素可使人胃黏膜上皮永生细胞系细胞的CDK4蛋白表达及其激酶活性增加。结论 蛙皮素促进人胃黏膜上皮细胞生长是通过使细胞周期调控因子cyclin D1和CDK4蛋白表达升高，CDK4激酶活性增加，促进细胞周期的进展而实现的。" @default.
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- W896613488 date "2001-06-20" @default.
- W896613488 modified "2023-09-25" @default.
- W896613488 title "蛙皮素对人胃黏膜上皮永生细胞系cyclin D1／CDK4的影响" @default.
- W896613488 hasPublicationYear "2001" @default.
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