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• W896647986 abstract "Saxifragin, the 5-glucoside of the flavonoid quercetin, is found in plants and insects. It has been reported that saxifragin has peroxynitrite-scavenging effects. However, the mechanism of anti-inflammatory effects of saxifragin has not yet been clearly identified. In this study, we investigated the anti-inflammatory effects of saxifragin in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and animal models of inflammation. We found that saxifragin suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-activated RAW 264.7 macrophages by suppressing the level of protein and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively. Furthermore, saxifragin inhibited mRNA expression of pro-inflammatory cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β. We studied the inhibitory effects of saxifragin on the nuclear translocation of nuclear factor (NF)-κB, activation of caspase-1, and phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK). Furthermore, pretreatment with saxifragin increased the survival rate of mice with LPS-induced septic death. Collectively, these findings suggest that saxifragin exerts anti-inflammatory activity by inhibiting NF-κB, caspase-1, and mitogen-activated protein kinase (MAPK) activation." @default.
• W896647986 created "2016-06-24" @default.
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• W896647986 date "2015-07-14" @default.
• W896647986 modified "2023-10-16" @default.
• W896647986 title "Anti-inflammatory Activity of Saxifragin via Inhibition of NF-κB Involves Caspase-1 Activation" @default.
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• W896647986 doi "https://doi.org/10.1021/acs.jnatprod.5b00145" @default.
• W896647986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26171782" @default.
• W896647986 hasPublicationYear "2015" @default.
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