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- W89698402 abstract "The successes and failures of immunotherapy have made desirable and necessary the development of an immunopharmacology – a science of therapeutic immunoregulation. As a contribution to its development, it is essential through in vitro studies to define cellular targets of drug action, to analyze dose-response characteristics as they relate to specific immune functions, and to probe mechanisms of actions. The actions of biologicals such as the thymic hormones, interferons, and lymphokines, and of pharmacologic agents such as levamisole, isoprinosine, NPT 15392, azimexone, and muramyl dipeptide on cellular functions such as differentiation, proliferation, secretion, activation, and motility, are discussed. Aspects of their mechanisms of action as they relate to cyclic nucleotide messenger systems are briefly reviewed. The principles of their application in vivo as they relate to the type of agent, host characteristics, immune response variables, and the nature of the challenge in a particular disease are developed in an interactive equation. The ultimate predictive capactiy of such a science, once developed, is stressed." @default.
- W89698402 created "2016-06-24" @default.
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- W89698402 date "1981-01-01" @default.
- W89698402 modified "2023-09-27" @default.
- W89698402 title "The Immunopharmacology of Immunotherapy: an Update" @default.
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- W89698402 doi "https://doi.org/10.1016/b978-0-08-026384-7.50039-2" @default.
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