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- W897164061 abstract "Variability of outer surface proteins described among different genospecies of Borrelia burgdorferi is responsible for the lack of full protection of vaccinated dogs against challenge with heterologous spirochete strains. Due to that, the incorporation of multiple isolates or protein subunits may be necessary to increase the effectiveness of the vaccines. An experimental vaccine developed by the authors contained 4 strains of B. burgdorferi representing genospecies of spirochete prevalent in Poland. IgM antibodies of titre 200/400 were demonstrated in all vaccinated puppies, on day 7 after immunization. Their titre was increasing up to day 14 reaching the value of 800/1600. Between day 35 and 42 after vaccination the level of IgM antibodies decreased to 400. IgG antibodies of titre 200 were demonstrated in all vaccinated animals on day 7. Their level increased between day 7 and 21 after immunization up to 400/800 and then decreased to the value of 200/400, despite of the revaccination of animals. The results of the presented studies confirmed safety and immunogenic properties of an experimental vaccine against B. burgdorferi infection in dogs." @default.
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- W897164061 date "2002-01-01" @default.
- W897164061 modified "2023-09-23" @default.
- W897164061 title "Development and immunogenic properties of experimental vaccine against Lyme disease in dogs" @default.
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