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• W8972033 abstract "balance is protective, and if so, how can we best achieve that goal? Nutrients, in general, do not lend themselves to a research design that is best suited for pharmacological interventions because, unlike pharmaceuticals, nutrients are multi-functional substances built into our evolutionary design. There are many confounding factors in any randomized trial and meta-analysis. The vagaries in individual diets, habits, pre-clinical and clinical disease, genomic diversity of SNPs (single nucleotide polymorphisms), the bioavailability and biological specificity of different forms of individual nutrients, and selection of the most effective combinations of nutrients, make nutritional research through randomized trials and metaanalyses very problematic. Given that a methodologically sound, definitive randomized placebo-controlled trial has not been done and may never be done, the best we can currently do is take the best available evidence from basic science, studies of redox status, nutrient levels, trials with clearly measurable intermediate endpoints, relevant biomarkers, gene expression analysis, along with observational data and large-scale randomized trials and then synthesize all the points of evidence into a biologically plausible theory, clinical guidelines and when justified public policy. This was not done. Meta-analysis confronts us with many methodological difficulties including publication bias; heterogeneity of the trials; variations in quality, design and purpose of the individual trials, as well as the fact that the findings are often not borne out in later randomized trials on the same subject. LeLorier admonishes us that “the popularity of meta-analysis may at least partly come from the fact that it makes life simpler and easier for reviewers as well as readers. However, oversimplification may lead to inappropriate conclusions.” Furthermore, conclusions of many studies noted in abstracts of major journals are at odds with data published in the same paper. This oversimplification and conclusions inconsistent with the data were evident in the recent-metanalysis on vitamin E." @default.
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• W8972033 date "2005-02-17" @default.
• W8972033 modified "2023-09-23" @default.
• W8972033 title "A rational approach to antioxidant therapy and vitamin E." @default.
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