Matches in SemOpenAlex for { <https://semopenalex.org/work/W89742480> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W89742480 abstract "Efforts continue to identify and validate novel risk factors / biomarkers for breast cancer and improve current risk prediction models in the general population due to ongoing issues with sensitivity and specificity.The overall goal of this PhD study is to add to this effort. Specific aims are to (1) examine which is the best source of getting notified for breast cancer diagnosis in the general population since accurate data is crucial for risk assessment studies (2) investigate the association of sex steroids, gonadotrophins and novel assays of sex steroid hormone receptor serum bioactivity (SB) in breast cancer (3) examine whether they can be combined to improve breast cancer risk assessment and (4) identify new DNA methylation markers that might add to such a strategy in the future. To achieve this, a nested case-control study was undertaken within UK Collaborative Trial of Ovarian Cancer Screening.2629 trial participants were identified via cancer registry (CR) or self-reporting to have breast cancer. Diagnosis was confirmed by the treating clinician. The largest study was undertaken in England and Wales to examine completeness of breast cancer diagnosis within UKCTOCS. Analysis of complete data obtained in 1083 of these women showed CR to be more accurate than self-reporting but associated with time-delays.Serum samples from 200 eligible breast cancer cases identified through the process and 400 matched-controls were analysed for oestradiol, free-oestradiol, oestrone, androstenedione, testosterone, free-testosterone, progesterone, dehydroepiandrosterone sulphate (DHEAS), sex steroid hormone binding globulin (SHBG), luteinising hormone (LH), follicle stimulating hormone (FSH) and oestrogen receptor-α and -β and androgen receptor SB. Results showed that sex steroid receptor SB assays could add to breast cancer risk prediction. Additionally, the best oestrogen for breast cancer risk prediction is oestrone and the best androgen is testosterone. High testosterone and FSH levels up to 5 years prior to diagnosis predict breast cancer with high power and may have a synergistic effect.In a separate case control study of 189 paraffin-embedded breast tissue samples, 55 genes were investigated using MethyLight. DNA methylation alterations were found to be homogeneous in breast cancer with 13 genes being predictive of the disease, suggesting that such changes could be useful as future biomarkers.Further studies (already underway) involve using high-throughput technology to analyse serum DNA methylation changes and correlate these with the observed serum hormonal changes and build better breast cancer risk prediction models." @default.
- W89742480 created "2016-06-24" @default.
- W89742480 creator A5020720349 @default.
- W89742480 date "2011-02-28" @default.
- W89742480 modified "2023-09-26" @default.
- W89742480 title "Risk factors and novel biomarkers in breast cancer" @default.
- W89742480 hasPublicationYear "2011" @default.
- W89742480 type Work @default.
- W89742480 sameAs 89742480 @default.
- W89742480 citedByCount "0" @default.
- W89742480 crossrefType "dissertation" @default.
- W89742480 hasAuthorship W89742480A5020720349 @default.
- W89742480 hasConcept C121608353 @default.
- W89742480 hasConcept C126322002 @default.
- W89742480 hasConcept C134018914 @default.
- W89742480 hasConcept C143998085 @default.
- W89742480 hasConcept C2776683971 @default.
- W89742480 hasConcept C2777911890 @default.
- W89742480 hasConcept C2778575703 @default.
- W89742480 hasConcept C2779279165 @default.
- W89742480 hasConcept C2779279991 @default.
- W89742480 hasConcept C2908647359 @default.
- W89742480 hasConcept C29456083 @default.
- W89742480 hasConcept C30092816 @default.
- W89742480 hasConcept C530470458 @default.
- W89742480 hasConcept C71315377 @default.
- W89742480 hasConcept C71924100 @default.
- W89742480 hasConcept C99454951 @default.
- W89742480 hasConceptScore W89742480C121608353 @default.
- W89742480 hasConceptScore W89742480C126322002 @default.
- W89742480 hasConceptScore W89742480C134018914 @default.
- W89742480 hasConceptScore W89742480C143998085 @default.
- W89742480 hasConceptScore W89742480C2776683971 @default.
- W89742480 hasConceptScore W89742480C2777911890 @default.
- W89742480 hasConceptScore W89742480C2778575703 @default.
- W89742480 hasConceptScore W89742480C2779279165 @default.
- W89742480 hasConceptScore W89742480C2779279991 @default.
- W89742480 hasConceptScore W89742480C2908647359 @default.
- W89742480 hasConceptScore W89742480C29456083 @default.
- W89742480 hasConceptScore W89742480C30092816 @default.
- W89742480 hasConceptScore W89742480C530470458 @default.
- W89742480 hasConceptScore W89742480C71315377 @default.
- W89742480 hasConceptScore W89742480C71924100 @default.
- W89742480 hasConceptScore W89742480C99454951 @default.
- W89742480 hasLocation W897424801 @default.
- W89742480 hasOpenAccess W89742480 @default.
- W89742480 hasPrimaryLocation W897424801 @default.
- W89742480 hasRelatedWork W107140107 @default.
- W89742480 hasRelatedWork W1530552652 @default.
- W89742480 hasRelatedWork W1548224867 @default.
- W89742480 hasRelatedWork W1734658694 @default.
- W89742480 hasRelatedWork W1972033002 @default.
- W89742480 hasRelatedWork W1989898386 @default.
- W89742480 hasRelatedWork W2002081976 @default.
- W89742480 hasRelatedWork W2011369547 @default.
- W89742480 hasRelatedWork W2016808506 @default.
- W89742480 hasRelatedWork W2017682664 @default.
- W89742480 hasRelatedWork W2085008897 @default.
- W89742480 hasRelatedWork W2144809107 @default.
- W89742480 hasRelatedWork W2149907219 @default.
- W89742480 hasRelatedWork W2154816691 @default.
- W89742480 hasRelatedWork W2181390022 @default.
- W89742480 hasRelatedWork W2336502764 @default.
- W89742480 hasRelatedWork W2346890481 @default.
- W89742480 hasRelatedWork W2550678822 @default.
- W89742480 hasRelatedWork W3142334225 @default.
- W89742480 hasRelatedWork W567848048 @default.
- W89742480 isParatext "false" @default.
- W89742480 isRetracted "false" @default.
- W89742480 magId "89742480" @default.
- W89742480 workType "dissertation" @default.