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- W897554114 abstract "This chapter discusses the metabolism of capsaicin—a pungent principle of red pepper—with rat liver homogenates in vitro. Capsaicin is the main pungent principle of red pepper. Capsaicin and its homologs, that is, capsaicinoids, have been used in medicine internally and externally. In large doses, capsaicin can cause damage to gastric mucosa and may induce hepatitis. The chapter presents the evidence that capsaicin is metabolized in liver by a mixed function oxidase system. Several other synthetic capsaicinoids and zingerone were also studied with the liver enzyme to find out the structure-activity relationship. The chapter describes a study in which an attempt was made to determine whether the rat liver enzyme system could metabolize capsaicinoids. It was proved by detecting a metabolite that a microsomal enzyme preparation from locally available adult rats—mixed strain—could oxidize capsaicin. This function of oxidation was much enhanced by administration of sodium phenobarbital." @default.
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- W897554114 date "1980-01-01" @default.
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- W897554114 title "METABOLISM IN VITRO OF CAPSAICIN, A PUNGENT PRINCIPLE OF RED PEPPER, WITH RAT LIVER HOMOGENATES" @default.
- W897554114 doi "https://doi.org/10.1016/b978-0-12-187702-6.50085-2" @default.
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