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Matches in SemOpenAlex for { <https://semopenalex.org/work/W89779575> ?p ?o ?g. }

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• W89779575 abstract "A novel prostate cancer cell line (PC-J) was isolated from an androgen independent non-prostate specific antigen (non-PSA) producing carcinoma cell line. The homologous correlation between PC-J and PC-3 was determined by short tandem repeat analysis. The PSA promoter activity was detected by transient expression assay in the PC-J and LNCaP cells but not in androgen insensitive PC-3 cells. When the PC-J cells were cotransfected with androgen receptor, androgen receptor coactivators and PSA reporter vector cells, the reporter assays indicated that nuclear receptor coactivator 4 (NCOA4) but not androgen receptor activator 24 (ARA24) increased the sensitivity and maximum stimulation of dihydrotestosterone (DHT)-inducing PSA promoter activity. The RT-PCR assays revealed that the expression of several tumor markers, including interleukin-6, prostate stem cell antigen (PSCA), prostate epithelium-specific Ets transcription factor (PDEF) and matriptase, was lower in the PC-J cells than in the PC-3 cells. This cell model elucidated the regulation of PSA expression and enabled comparison of the gene profile at different stages of metastasis in prostatic carcinoma." @default.
• W89779575 created "2016-06-24" @default.
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• W89779575 date "2008-07-25" @default.
• W89779575 modified "2023-09-29" @default.
• W89779575 title "Prostate specific antigen gene expression in androgen insensitive prostate carcinoma subculture cell line." @default.
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• W89779575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18649734" @default.
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