Matches in SemOpenAlex for { <https://semopenalex.org/work/W898210892> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W898210892 endingPage "594" @default.
- W898210892 startingPage "590" @default.
- W898210892 abstract "AIM: Initial report on the in situ examination of the mRNA expression of transforming growth factor betas (TGFβs),TGFβ type Ⅱ receptor (TβRII) and telomerase activity in the experimental rat liver tissue during cholangiocarcinogenesis.METHODS: Rat liver cholangiocarcinogenesis was induced by 3'-methyl 4-dimethylazobenzene (3'Me-DAB). In situhybridization was used to examine the TGFβs) and TGFβ type Ⅱ receptor (TβRⅡ) mRNA, in situ TRAP was used to check the telomerase activity in the tissue samples.RESULTS: There was no TGFβs, TβRⅡ mRNA expression or telomerase activity in the control rat cholangiocytes. The expression of TGFβ1, TβRⅡ was increased in regenerative,hyperplastic, dysplastic cholangiocytes and cholangiocarcinoma (CC) cells. The expression of TGFβ2 mRNA was observed in only a part of hyperplastic, dysplastic cholangiocytes. TGFβ3expression was very weak, only in hyperplastic lesion. There was positive telomerase activity in the regenerative,hyperplastic, dysplastic cholangiocytes, and CC cells. Stroma fibroblasts of these lesions also showed positive TGFβs, TβRⅡ mRNA expression and telomerase activity.CONCLUSION: There were TGFβs, TβRⅡ expression and telomerase activity in hyperplastic, dysplastic cholangiocytes,cholangiocarcinoma cells as well as in stroma fibroblasts during cholangiocarcinogenesis. Their expression or activity is important in cholangiocarcinogenesis andstroma formation." @default.
- W898210892 created "2016-06-24" @default.
- W898210892 creator A5009840117 @default.
- W898210892 creator A5031696578 @default.
- W898210892 creator A5037935289 @default.
- W898210892 creator A5041833533 @default.
- W898210892 creator A5044042215 @default.
- W898210892 creator A5078914866 @default.
- W898210892 creator A5085113684 @default.
- W898210892 date "2003-01-01" @default.
- W898210892 modified "2023-09-24" @default.
- W898210892 title "In situ detection of TGF betas, TGF beta receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis" @default.
- W898210892 hasPublicationYear "2003" @default.
- W898210892 type Work @default.
- W898210892 sameAs 898210892 @default.
- W898210892 citedByCount "0" @default.
- W898210892 crossrefType "journal-article" @default.
- W898210892 hasAuthorship W898210892A5009840117 @default.
- W898210892 hasAuthorship W898210892A5031696578 @default.
- W898210892 hasAuthorship W898210892A5037935289 @default.
- W898210892 hasAuthorship W898210892A5041833533 @default.
- W898210892 hasAuthorship W898210892A5044042215 @default.
- W898210892 hasAuthorship W898210892A5078914866 @default.
- W898210892 hasAuthorship W898210892A5085113684 @default.
- W898210892 hasConcept C104317684 @default.
- W898210892 hasConcept C105580179 @default.
- W898210892 hasConcept C118131993 @default.
- W898210892 hasConcept C142724271 @default.
- W898210892 hasConcept C153911025 @default.
- W898210892 hasConcept C203014093 @default.
- W898210892 hasConcept C204232928 @default.
- W898210892 hasConcept C2778229498 @default.
- W898210892 hasConcept C502942594 @default.
- W898210892 hasConcept C52124034 @default.
- W898210892 hasConcept C54355233 @default.
- W898210892 hasConcept C71924100 @default.
- W898210892 hasConcept C81439078 @default.
- W898210892 hasConcept C86803240 @default.
- W898210892 hasConcept C94581717 @default.
- W898210892 hasConcept C95444343 @default.
- W898210892 hasConceptScore W898210892C104317684 @default.
- W898210892 hasConceptScore W898210892C105580179 @default.
- W898210892 hasConceptScore W898210892C118131993 @default.
- W898210892 hasConceptScore W898210892C142724271 @default.
- W898210892 hasConceptScore W898210892C153911025 @default.
- W898210892 hasConceptScore W898210892C203014093 @default.
- W898210892 hasConceptScore W898210892C204232928 @default.
- W898210892 hasConceptScore W898210892C2778229498 @default.
- W898210892 hasConceptScore W898210892C502942594 @default.
- W898210892 hasConceptScore W898210892C52124034 @default.
- W898210892 hasConceptScore W898210892C54355233 @default.
- W898210892 hasConceptScore W898210892C71924100 @default.
- W898210892 hasConceptScore W898210892C81439078 @default.
- W898210892 hasConceptScore W898210892C86803240 @default.
- W898210892 hasConceptScore W898210892C94581717 @default.
- W898210892 hasConceptScore W898210892C95444343 @default.
- W898210892 hasIssue "3" @default.
- W898210892 hasLocation W8982108921 @default.
- W898210892 hasOpenAccess W898210892 @default.
- W898210892 hasPrimaryLocation W8982108921 @default.
- W898210892 hasRelatedWork W1986019421 @default.
- W898210892 hasRelatedWork W1996598536 @default.
- W898210892 hasRelatedWork W2007156276 @default.
- W898210892 hasRelatedWork W2007169157 @default.
- W898210892 hasRelatedWork W2038208478 @default.
- W898210892 hasRelatedWork W2044020710 @default.
- W898210892 hasRelatedWork W2049014840 @default.
- W898210892 hasRelatedWork W2071524402 @default.
- W898210892 hasRelatedWork W2095053136 @default.
- W898210892 hasRelatedWork W2147770529 @default.
- W898210892 hasRelatedWork W2348097944 @default.
- W898210892 hasRelatedWork W2355029770 @default.
- W898210892 hasRelatedWork W2419562133 @default.
- W898210892 hasRelatedWork W2474594928 @default.
- W898210892 hasRelatedWork W2978432494 @default.
- W898210892 hasRelatedWork W3132426651 @default.
- W898210892 hasRelatedWork W63149615 @default.
- W898210892 hasRelatedWork W2429592862 @default.
- W898210892 hasRelatedWork W2740110016 @default.
- W898210892 hasRelatedWork W2740394160 @default.
- W898210892 hasVolume "9" @default.
- W898210892 isParatext "false" @default.
- W898210892 isRetracted "false" @default.
- W898210892 magId "898210892" @default.
- W898210892 workType "article" @default.