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• W898713277 abstract "Made available in DSpace on 2015-05-14T16:53:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-02-27Bitstream added on 2015-05-14T16:59:01Z : No. of bitstreams: 1 000828052_20150610.pdf: 305956 bytes, checksum: 7369e2c8e287bd85ed19449e6cb2b2e6 (MD5) Bitstreams deleted on 2015-06-12T11:19:08Z: 000828052_20150610.pdf,. Added 1 bitstream(s) on 2015-06-12T11:19:39Z : No. of bitstreams: 1 000828052.pdf: 458163 bytes, checksum: 8f3277eff5562c7da6c209cf3706a1c0 (MD5)%%%%A imipramina e antidepressivo triciclico cujo principal mecanismo e a inibicao da captura neuronal de noradrenalina e/ou serotonina, aumentando os niveis sinapticos dessas monoaminas. Alem disso, a imipramina, bem como outros antidepressivos triciclicos, antagonizam os adrenoceptores α1 na mesma faixa de concentracao em que inibem o transportador de noradrenalina. Por outro lado, estudos recentes mostraram que a imipramina tem afinidades distintas para os tres subtipos deadrenoceptores α1, (α1A, α1B e α1D), ou seja, aproximadamente 25 vezes mais seletiva para α1A em relacao aos adrenoceptores α1B e 10 vezes para adrenoceptores α1D em relacao aos adrenoceptores α1B. Isso sugere que seu mecanismo de acao possa estar relacionado com essa caracteristica, uma vez que, ao aumentar os niveis sinapticos de noradrenalina, antagoniza α1A e α1D, mas deixa relativamente livre α1B. Entao, o objetivo desta tese foi investigar a participacao dos adrenoceptores α1A, α1B e α1D no efeito anti-imobilidade da imipramina no teste de suspensao pela cauda em camundongos. Para isso, camundongos foram submetidos ao teste de suspensao pela cauda, com a administracao de diversos antagonistas seletivos e nao-seletivos para subtipos α1. Os testes foram realizados utilizando a imipramina associada ao prazosin, antagonista nao-seletivo para adrenoceptores α1, RS-100329, antagonista seletivo pra α1A, L-765314, seletivo par α1B e BMY-7378, seletivo para α1D. Os animais tambem foramavaliados com administracoes unicas dos antagonistas. Esta tese mostrou que a administracao concomitante de prazosin ou o L-765314 reverteram o efeito anti-imobilidade da imipramina. Por outro lado, nem o RS-100329 ou BMY-7378 modificaram o efeito anti-imobilidade da imipramina. Alem disso, a administracao de apenas o RS-100329 ou BMY-7378 apresentou efeito anti-imobilidade no teste de suspensao pela cauda. Isso indica que o efeito ...%%%%Imipramine is a tricyclic antidepressant inhibitor of norepinephrine and serotonin neuronal reuptake. In addition, the imipramine antagonizes α1-adrenoceptors in the same concentration range that inhibited norepinephrine transporter. However, the imipramine has different affinity to α1-adrenoceptor subtypes presenting higher affinity (10-25-fold) towards α1A- and α1D-adrenoceptors compared to α1B-adrenoceptors. This study investigates the α1-adrenoceptor subtypes involved in the anti-immobility effect of imipramine in the tail suspension test inmice. The anti-immobility effect of imipramine was significantly antagonized by the non-subtype-selective…" @default.
• W898713277 created "2016-06-24" @default.
• W898713277 creator A5032625426 @default.
• W898713277 date "2015-02-27" @default.
• W898713277 modified "2023-09-23" @default.
• W898713277 title "Investigação do envolvimento de subtipos de adrenoceptores α1 no efeito anti-imobilidade da imipramina no teste de suspensão pela cauda" @default.
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