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- W899182804 abstract "Objective To investigate the effects of Rosiglitazone on expressions of MMP-2 and TIMP-1 mRNA in hepatic stellate cells(HSCs) in vitro.Methods The HSC line,HSC-T6 was incubated with different concentrations of Rosiglitazone.The MMP-2 and TIMP-1 mRNA levels were measured by reverse-transcription polymerase chain reaction(RT-PCR).Results Expression of TIMP-1 mRNA in the Rosiglitazone-treatment groups was significantly lower than that in the control group(P0.05),and there was no difference in the MMP-2 mRNA levels between the Rosiglitazone-treatment groups and the control group.Conclusion The anti-fibrosis mechanism of Rosiglitazone is partly due to its down-regulation on TIMP-1 but not on MMP-2 expression of hepatic stellate cells." @default.
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- W899182804 date "2009-01-01" @default.
- W899182804 modified "2023-09-24" @default.
- W899182804 title "Effects of Rosiglitazone on expressions of MMP-2 and TIMP-1 mRNA in hepatic stellate cells." @default.
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