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• W89943134 abstract "Research Article1 June 1994free access Evolution of a disrupted TAR RNA hairpin structure in the HIV-1 virus. B. Klaver B. Klaver University of Amsterdam, Department of Virology, Academic Medical Center, The Netherlands. Search for more papers by this author B. Berkhout B. Berkhout University of Amsterdam, Department of Virology, Academic Medical Center, The Netherlands. Search for more papers by this author B. Klaver B. Klaver University of Amsterdam, Department of Virology, Academic Medical Center, The Netherlands. Search for more papers by this author B. Berkhout B. Berkhout University of Amsterdam, Department of Virology, Academic Medical Center, The Netherlands. Search for more papers by this author Author Information B. Klaver1 and B. Berkhout1 1University of Amsterdam, Department of Virology, Academic Medical Center, The Netherlands. The EMBO Journal (1994)13:2650-2659https://doi.org/10.1002/j.1460-2075.1994.tb06555.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Human immunodeficiency virus type 1 (HIV-1) RNA contains an extended hairpin structure at the 5′ end (the TAR element) that is essential for viral replication. The upper part of the stem-loop structure binds the virally encoded transcriptional activator protein Tat and cellular co-factors, but no clear function for the lower stem region has been established. Here, we report that mutant HIV-1 viruses with base substitutions in the lower stem region are dead, most likely at the level of transcription from an integrated provirus. By using large amounts of these mutant DNA constructs for transfections, revertant viruses with a great variety of genetic changes (point mutations, short deletions) could be isolated in prolonged culture experiments that lasted over 6 months. The pattern and evolution of these changes supported the notion that base-pairing of the lower stem region is essential for optimal HIV-1 replication. The functional and genetic plasticities of this RNA domain and the HIV-1 long terminal repeat promoter are discussed. Previous ArticleNext Article Volume 13Issue 111 June 1994In this issue RelatedDetailsLoading ..." @default.
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• W89943134 date "1994-06-01" @default.
• W89943134 modified "2023-10-18" @default.
• W89943134 title "Evolution of a disrupted TAR RNA hairpin structure in the HIV-1 virus." @default.
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• W89943134 doi "https://doi.org/10.1002/j.1460-2075.1994.tb06555.x" @default.
• W89943134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/395139" @default.
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