Matches in SemOpenAlex for { <https://semopenalex.org/work/W899490711> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W899490711 abstract "Purpose: Medical intervention following a major, unplanned radiation event can elevate the human whole body exposure LD50 from 3 to 7 Gy. On a large scale, intervention cannot be achieved effectively without accurate and efficient triage. Current methods of retrospective biodosimetry are restricted in capability and applicability; published human data is limited. We aim to further develop, validate, and optimize an automated field-deployable in vivo electron paramagnetic resonance (EPR) instrument that can fill this need. Methods: Ionizing radiation creates highly-stable, carbonate-based free radicals within tooth enamel. Using a process similar to nuclear magnetic resonance, EPR directly measures the presence of radiation-induced free radicals. We performed baseline EPR measurements on one of the upper central incisors of total body irradiation (TBI) and head and neck (H&N) radiotherapy patients before their first treatment. Additional measurements were performed between subsequent fractions to examine the EPR response with increasing radiation dose. Independent dosimetry measurements were performed with optically-stimulated luminescent dosimeters (OSLDs) and diodes to more accurately establish the relationship between EPR signal and delivered radiation dose. Results: 36 EPR measurements were performed over the course of four months on two TBI and four H & N radiotherapy patients. We observe a linear increase inmore » EPR signal with increasing dose across the entirety of the tested range. A linear least squares-weighted fit of delivered dose versus measured signal amplitude yields an adjusted R-square of 0.966. The standard error of inverse prediction (SEIP) is 1.77 Gy. For doses up to 7 Gy, the range most relevant to triage, we calculate an SEIP of 1.29 Gy. Conclusion: EPR spectroscopy provides a promising method of retrospective, non-invasive, in vivo biodosimetry. Our preliminary data show an excellent correlation between predicted signal amplitude and delivered dose. With further development, a robust means of predicting delivered radiation dose from EPR measurements is expected. This project was funded by the Biomedical Advanced Research and Development Authority (BARDA) within the U.S. Department of Health and Human Services subcontracted through the Geisel School of Medicine at Dartmouth and by the Dartmouth Physically-Based Biodosimetry Center for Medical Countermeasures Against Radiation (Dart-Dose CMCR) Pilot Program.« less" @default.
- W899490711 created "2016-06-24" @default.
- W899490711 creator A5000084530 @default.
- W899490711 creator A5011053774 @default.
- W899490711 creator A5024172649 @default.
- W899490711 creator A5025519576 @default.
- W899490711 creator A5035255307 @default.
- W899490711 creator A5041869023 @default.
- W899490711 creator A5049742310 @default.
- W899490711 creator A5071122480 @default.
- W899490711 creator A5072239906 @default.
- W899490711 creator A5077059767 @default.
- W899490711 creator A5083596379 @default.
- W899490711 creator A5086525997 @default.
- W899490711 date "2015-06-01" @default.
- W899490711 modified "2023-09-27" @default.
- W899490711 title "SU-C-BRD-05: Non-Invasive in Vivo Biodosimetry in Radiotherapy Patients Using Electron Paramagnetic Resonance (EPR) Spectroscopy" @default.
- W899490711 doi "https://doi.org/10.1118/1.4923800" @default.
- W899490711 hasPublicationYear "2015" @default.
- W899490711 type Work @default.
- W899490711 sameAs 899490711 @default.
- W899490711 citedByCount "5" @default.
- W899490711 countsByYear W8994907112016 @default.
- W899490711 countsByYear W8994907112018 @default.
- W899490711 countsByYear W8994907112020 @default.
- W899490711 crossrefType "journal-article" @default.
- W899490711 hasAuthorship W899490711A5000084530 @default.
- W899490711 hasAuthorship W899490711A5011053774 @default.
- W899490711 hasAuthorship W899490711A5024172649 @default.
- W899490711 hasAuthorship W899490711A5025519576 @default.
- W899490711 hasAuthorship W899490711A5035255307 @default.
- W899490711 hasAuthorship W899490711A5041869023 @default.
- W899490711 hasAuthorship W899490711A5049742310 @default.
- W899490711 hasAuthorship W899490711A5071122480 @default.
- W899490711 hasAuthorship W899490711A5072239906 @default.
- W899490711 hasAuthorship W899490711A5077059767 @default.
- W899490711 hasAuthorship W899490711A5083596379 @default.
- W899490711 hasAuthorship W899490711A5086525997 @default.
- W899490711 hasConcept C105636585 @default.
- W899490711 hasConcept C111337013 @default.
- W899490711 hasConcept C121332964 @default.
- W899490711 hasConcept C126838900 @default.
- W899490711 hasConcept C143409427 @default.
- W899490711 hasConcept C18231593 @default.
- W899490711 hasConcept C185544564 @default.
- W899490711 hasConcept C187961010 @default.
- W899490711 hasConcept C192562407 @default.
- W899490711 hasConcept C2779254040 @default.
- W899490711 hasConcept C2989005 @default.
- W899490711 hasConcept C46141821 @default.
- W899490711 hasConcept C509974204 @default.
- W899490711 hasConcept C63007395 @default.
- W899490711 hasConcept C71924100 @default.
- W899490711 hasConcept C75088862 @default.
- W899490711 hasConceptScore W899490711C105636585 @default.
- W899490711 hasConceptScore W899490711C111337013 @default.
- W899490711 hasConceptScore W899490711C121332964 @default.
- W899490711 hasConceptScore W899490711C126838900 @default.
- W899490711 hasConceptScore W899490711C143409427 @default.
- W899490711 hasConceptScore W899490711C18231593 @default.
- W899490711 hasConceptScore W899490711C185544564 @default.
- W899490711 hasConceptScore W899490711C187961010 @default.
- W899490711 hasConceptScore W899490711C192562407 @default.
- W899490711 hasConceptScore W899490711C2779254040 @default.
- W899490711 hasConceptScore W899490711C2989005 @default.
- W899490711 hasConceptScore W899490711C46141821 @default.
- W899490711 hasConceptScore W899490711C509974204 @default.
- W899490711 hasConceptScore W899490711C63007395 @default.
- W899490711 hasConceptScore W899490711C71924100 @default.
- W899490711 hasConceptScore W899490711C75088862 @default.
- W899490711 hasLocation W8994907111 @default.
- W899490711 hasOpenAccess W899490711 @default.
- W899490711 hasPrimaryLocation W8994907111 @default.
- W899490711 hasRelatedWork W1965063187 @default.
- W899490711 hasRelatedWork W1968245319 @default.
- W899490711 hasRelatedWork W1972133503 @default.
- W899490711 hasRelatedWork W1977865667 @default.
- W899490711 hasRelatedWork W1994093435 @default.
- W899490711 hasRelatedWork W2021531729 @default.
- W899490711 hasRelatedWork W2042849654 @default.
- W899490711 hasRelatedWork W2072149615 @default.
- W899490711 hasRelatedWork W2092823609 @default.
- W899490711 hasRelatedWork W2158295822 @default.
- W899490711 hasRelatedWork W2332608571 @default.
- W899490711 hasRelatedWork W2414143130 @default.
- W899490711 hasRelatedWork W2511745878 @default.
- W899490711 hasRelatedWork W2725495606 @default.
- W899490711 hasRelatedWork W2754716972 @default.
- W899490711 hasRelatedWork W3094381217 @default.
- W899490711 hasRelatedWork W3146983598 @default.
- W899490711 hasRelatedWork W46317949 @default.
- W899490711 hasRelatedWork W2101836876 @default.
- W899490711 hasRelatedWork W2798863996 @default.
- W899490711 isParatext "false" @default.
- W899490711 isRetracted "false" @default.
- W899490711 magId "899490711" @default.
- W899490711 workType "article" @default.