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- W89950457 endingPage "817" @default.
- W89950457 startingPage "785" @default.
- W89950457 abstract "This chapter describes the inorganic chemistry of the metallic radionuclides of copper, gallium, and indium with a main focus on technetium for diagnostic imaging in nuclear medicine. Other radionuclides are mentioned as well where appropriate. The application of radionuclides to patients requires complexes which are in vivo stable and do not trans-metallate to the numerous competing coordination sites in proteins and other endogenous biomolecules. Site-directed delivery and accumulation at target sites are achieved by combining a metal complex with a receptor-binding vector. The introductory part describes in detail the background of inorganic chemistry for imaging in order to clarify the numerous constraints related to metallic radionuclides in imaging. These particular requirements, in vivo stability and bioconjugation, shape the inorganic chemistry of these elements and are discussed in detail. Development of corresponding ligands, complex formation with the respective metal ions, and in vivo investigations are a focus. The chapter not only reviews the current state of the art but also aims to identify opportunities for future directions in medicinal inorganic drug development." @default.
- W89950457 created "2016-06-24" @default.
- W89950457 creator A5063303431 @default.
- W89950457 creator A5084844516 @default.
- W89950457 date "2013-01-01" @default.
- W89950457 modified "2023-10-03" @default.
- W89950457 title "SPECT/PET Imaging with Technetium, Gallium, Copper, and Other Metallic Radionuclides" @default.
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