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- W90013212 abstract "textabstractPrenatal diagnosis (PD) startcd in the fifties when variotls groups indicated the possibility ofprenatal sex determination in amniotic fluid (AF) cells (SeIT et al., 1955; Fuchs and Riis,1956; Dewhurst, 1956). After the first succesful attempts at AF cell cultivation andkaryotyping by SteeIe and Breg (1966) and T1tiede et al. (1966), the first small series ofprcnatal chromosomc analyses were presented (Jacobsoll aud Barter, 1967), aud the ficstchromosome aberrations in cultured AF cells were detected (Valenti et al., 1969). AF cellscould also be used for prenatal detcction of inham errors of metabolism (NadIer, 1968). Oureentre made an important international contribution towards experienee with a large numberof biochemical assays, and the devclopment of ultramicrochemical techlliques penllitting arapid PD (Galjaard, 1972; Niermeijer, 1975; Galjaard, 1976a, 1979, 1980; Galjaard et al.,1977; K1eijer, 1990). AtlOther important contribution to PD was the finding by Broek andSutcliffe (1972), that the alpha-fetoprotein level in AF is increascd when the fetus has an openneural tube defect." @default.
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- W90013212 date "1998-03-04" @default.
- W90013212 modified "2023-09-27" @default.
- W90013212 title "Molecular cytogenetics in prenatal diagnosis" @default.
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