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- W90046611 abstract "1506 Objectives: Positron emission tomography (PET) with 18F-FDG detects active lymphoid tissue during HIV-1 infection, with distinct patterns of lymphoid activation correlating to various stages of disease activity. Patients with HIV-1 are at risk for lymphoma, making the differential diagnosis between benign and malignant lymphadenopathy challenging. PET/CT has a well established role in the management of lymphoma. This study retrospectively evaluated the role of PET/CT in differentiating active lymphoma from persistent generalized lymphadenopthy in HIV-1 patients. Methods: Six HIV-1 patients with known lymphoma underwent a total of 15 PET/CT scans: 5/15 scans were performed for initial staging, and 10/15 for evaluating treatment response and follow-up. PET/CT findings were compared with concurrent clinical, immunological and virological data. Results: PET/CT accurately depicted the extent of lymphoma in 12/15 pts scans(80%), yet in 3/15 (20%) scans moderate-markedly increased FDG uptake was noted in lymph nodes of normal CT appearance (PET+/CT-). Viral loads ranged from 0 to 53,000 copies/ml, and CD4 T-cell count ranged from 130-474 cells/µl. The highest values of both parameters were concurrent with the discrepant PET+/CT- scans. PET (+) lymphadenopathy was observed in neck, axillae, mediastinum, spleen and inguinal regions, and sample biopsies of the positive nodes consequently proved benign findings. Conclusions: PET/CT accurately detected lymphoma in HIV-1 patients and had been used confidently as a management tool in this patient group. In the context of discrepant PET/CT findings, slightly increased viral loads and CD4 levels strongly implied benign HIV-related lymphadenopathy." @default.
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- W90046611 date "2007-05-01" @default.
- W90046611 modified "2023-09-23" @default.
- W90046611 title "PET/CT in the evaluation of lymphoma in HIV-1 patients with suppressed viral loads" @default.
- W90046611 hasPublicationYear "2007" @default.
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