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- W90075467 abstract "Prostate-specific antigen (PSA) remains the best available marker for the detection of prostate cancer and for monitoring evidence of recurrence after treatment; yet, it has limitations both as a diagnostic and as a prognostic tool when considered on its own. Methods to improve the predictive and prognostic significance of PSA have led to innovations such as considering the rate of rise in serial PSA levels prior to diagnosis of prostate cancer. PSA velocity has significant advantages over a single-PSA measurement not only in differentiating between men with prostate cancer and those with benign disease, but also in predicting the biological aggressiveness of prostate cancer at presentation. PSA velocity at presentation, and in particular an increase in the PSA level by more than 2 ng/ml during the year prior to diagnosis, is significantly associated with more advanced tumor stage, higher grade, and a shorter time to PSA failure, prostate cancer-specific and all-cause mortality following radical prostatectomy or radiation therapy in men with prostate cancer." @default.
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- W90075467 date "2009-01-01" @default.
- W90075467 modified "2023-10-15" @default.
- W90075467 title "PSA Velocity at Presentation as a Predictor of Prostate Cancer Aggressiveness" @default.
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- W90075467 doi "https://doi.org/10.1007/978-1-60327-281-0_9" @default.
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