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- W90118059 abstract "Drug therapy for epilepsy dates back to the mid-nineteenth century, with approximately 20 drugs currently in use. These show differing efficacy depending on the type of epilepsy and the side effect liabilities of the different anticonvulsant drugs (AEDs). With the exception of vigabatrin and tiagabine (AEDs that produce their anticonvulsant effects by potentiating the effects of the endogenous inhibitory neurotransmitter GABA), the majority of AEDs have ill-defined mechanism(s) of action making it difficult to initiate de novo medicinal chemistry campaigns to find newer AEDs with improved safety profiles and broader anticonvulsant profiles. It has been argued that the social stigma related to epilepsy has limited research investment and progress." @default.
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- W90118059 date "2007-01-01" @default.
- W90118059 modified "2023-09-24" @default.
- W90118059 title "Epilepsy" @default.
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- W90118059 doi "https://doi.org/10.1016/b0-08-045044-x/00171-1" @default.
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