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- W901796723 abstract "目的检测趋化因子CXCL10（IP-10）启动子区G-201A位点的单核苷酸多态性（SNP）,探讨其与乙型肝炎病毒（HBV）感染慢性化及重症化的关系。方法采集302医院792例HBV感染患者血样,包括急性乙型肝炎（AHB）200例、轻中度慢性乙型肝炎（CHB-M）200例、重度慢性乙型肝炎（CHB-S）192例和慢加急肝衰竭（ACLF）200例,另采集300各正常人（NC）血样作为对照。提取DNA,PCR扩增与G-201位点变异连锁的C-1596区域片段,进行限制性片段长度多态性（PCR-RFLP）分析;同时从各组随机抽取400例样本,采用PCR产物直接测序法进行G-201位点区域片段的测序分析。对上述两种方法SNP分型结果的一致性进行分析。结果 G-201A的变异率为：AHB组17.77%,CHB-M组25.26%,CHB-S组26.59%,ACLF组21.28%,NC组13.82%,各组间总P=0.0037;相关性检验（P=0.0015）表明变异率与不同病程相关;经线性趋势检验,P=0.0029,Z=—2.9748,表明变异率随疾病进展呈现升高趋势。各组间两两比较发现,CHB-M、CHB-S、ACLF组与NC组之间的变异率有显著差异（P值分别为0.0024、0.0007、0.0428）;CHB-S组与AHB组之间的变异率有显著差异（P=0.0488）。PCR产物直接测序法与PCR-RFLP法检测结果的一致率为98.68%,Kappa检验得出U=58.425,P〈0.05,检测结果之间的一致性符合统计学要求。结论 IP-10启动子区G-201A变异与HBV感染慢性化相关,其与HBV感染重症化的关系尚需进一步研究。" @default.
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- W901796723 date "2011-01-01" @default.
- W901796723 modified "2023-10-18" @default.
- W901796723 title "趋化因子CXCL10 G-201A单核苷酸多态性与HBV感染慢性化和重症化关系的研究" @default.
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