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- W90184905 abstract "Parkinson korban a nucleus caudatusban a kronikus l-DOPA kezelesnek betudhato csokkent dopamin D2/D3 receptor sűrűseg mellett a receptor–G protein jelatvitel kontroll szinten marad, mely funkcionalis kompenzacio megnyilvanulasa lehet. A gyrus frontalis medialis es gyrus cinguli valtozatlan dopamin D2/D3 receptor denzitasa es szenzitivitasa alatamasztja a kulonboző agyi regiok elterő mertekű erintettseget es az extrasztriatalis tunetek fokozatos megjeleneset a Parkinson kor progresszioja soran. Az uj tipusu 125I-SD7015 CB1R ligand nagy erzekenyseggel detektalta a CB1R sűrűsegbeli kulonbsegeket kontroll es Alzheimer koros prefrontalis mintak kozott. Az Alzheimer kor (AK) korai stadiumaiban tapasztalt szignifikans CB1R denzitas emelkedes a cannabinoid rendszer neurodegeneraciora adott reaktiv megnyilvanulasa lehet, mely indokolja az AK Braak I-II neuropatologiai stadiumu agymintak kontrolltol kulonallo csoportba valo sorolasat. Az Alzheimer koros prefrontalis mintak illetve Parkinson koros putamen es nc caudatus mintak eseteben, a vizsgalt betegsegek vegső stadiumaiban is ep CB1R populacio alternativ kezelesi celpont lehet. Kalium-disztribucios eljarassal egyertelműen elkulonithető az ischaemias karosodast szenvedett agyterulet az ep regioktol 100 µm vastagsagu human teljes hemispherium metszeteken. A modszer kombinalhato a teljes feltekei autoradiografiaval es „terkepkent” szolgalhat a szomszedos agyteruletekkel valo osszehasonlitas es agyszovet mintavetel soran. | Despite the important reduction of dopamine (DA) D2/D3 binding sites in PD nucleus caudate, the increased sensitivity of the remained DA D2/D3 receptors maintains signal transduction effectiveness near to control levels, suggesting functional compensation of DA depletion. In PD middle frontal and cingulated gyrus DA D2/D3 receptor density and sensitivity were on control levels. This supports that dopaminergic neurotransmission of distinct PD brain regions is affected in different extent explaining the gradual appearance of extrastriatal symptoms during PD progression. The novel 125I-SD7015 radioligand (cannabinoid type-1 receptor - CB1R - agonist) detected with high precision CB1R density differences between control and AD prefrontal cortex specimens. In AD Braak I-II sample groups CB1R density was evidently above control levels, suggesting that Braak I-II samples should be studied separately from controls. During the whole progression of AD and PD CB1R densities in prefrontal cortex as well as putamen and nc caudate, respectively, remained on or above control levels showing that CB1R population could serve as alternative target for treatment. Potassium staining method unequivocally differentiated the infarcted brain areas from the intact regions in case of human whole hemisphere sections. This method can be combined with our autoradiographic techniques using whole hemisphere sections; this ’brainmap’ provides base of regional comparison and guide for targeted tissue sampling." @default.
- W90184905 created "2016-06-24" @default.
- W90184905 creator A5033422963 @default.
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- W90184905 date "2013-01-01" @default.
- W90184905 modified "2023-09-30" @default.
- W90184905 title "Agyi receptor-rendszerek vizsgálata neurológiai kórképekben: speciális és hagyományos autoradiográfiás módszerek alkalmazása Parkinson-kórban, Alzheimer-kórban és az öregedés során = Brain receptor-systems in neurological disorders: special and conventional autoradiographic methods in investigation of Parkinson-disease, Alzheimer-disease and aging" @default.
- W90184905 hasPublicationYear "2013" @default.
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