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• W901986987 abstract "Tissue macrophages function to maintain homeostasis and regulate immune responses. While tissue macrophages derive from one of a small number of progenitor programs, the transcriptional requirements for site-specific macrophage subset development are more complex. We have identified a new tissue macrophage subset in the thymus and have discovered that its development is dependent on transcription factor NR4A1. Functionally, we find that NR4A1-dependent macrophages are critically important for clearance of apoptotic thymocytes. These macrophages are largely reduced or absent in mice lacking NR4A1, and Nr4a1-deficient mice have impaired thymocyte engulfment and clearance. Thus, NR4A1 functions as a master transcription factor for the development of this novel thymus-specific macrophage subset." @default.
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• W901986987 date "2015-06-19" @default.
• W901986987 modified "2023-10-11" @default.
• W901986987 title "The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus" @default.
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• W901986987 doi "https://doi.org/10.1038/srep10055" @default.
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