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• W90202938 abstract "OBJECTIVE: To evaluate the frequency of AQP4-Ab in patients with HAM/TSP and asymptomatic HTLV-1 infection. To evaluate the frequency of HTLV-1 infection in patients with NMOSD. BACKGROUND: The seroprevalence of human T-cell leukemia virus type 1 (HTLV-1) is very high among Brazilians (∼1:200). HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP) is the most common neurological complication of HTLV-1 infection. HAM/TSP can present with an acute/subacute form of longitudinally extensive myelitis, which can be confused with lesions seen in aquaporin-4 antibody (AQP4-Ab) positive neuromyelitis optica spectrum disorders (NMOSD) on MRI. Moreover, clinical attacks in patients with NMOSD have been shown to be preceded by viral infections in around 30% of cases. DESIGN/METHODS: 23 Brazilian patients with HAM/TSP, 20 asymptomatic HTLV-1+ serostatus patients, and 34 with NMOSD were tested for AQP4-Ab using a standardized recombinant cell based assay. In addition, all patients were tested for HTLV-1 by ELISA and Western blotting. RESULTS: 20/34 NMOSD patients were positive for AQP4-Ab but none of the HAM/TSP patients and none of the asymptomatic HTLV-1 infected individuals. Conversely, all AQP4-Ab-positive NMOSD patients were negative for HTLV-1 antibodies. One patient with HAM/TSP developed optic neuritis in addition to subacute LETM; this patient was AQP4-Ab negative as well. Patients were found to be predominantly female and of African descent both in the NMOSD and in the HAM/TSP group; Osame scale and expanded disability status scale scores did not differ significantly between the two groups. CONCLUSIONS: Our results argue both against a role of antibodies to AQP4 in the pathogenesis of HAM/TSP and against an association between HTLV-1 infection and the development of AQP4-Ab. Moreover, the absence of HTLV-1 in all patients with NMOSD suggests that HTLV-1 is not a common trigger of acute attacks in patients with AQP4-Ab positive NMOSD in populations with high HTLV-1 seroprevalence. Supported by: Brazilian government agencies FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) and CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior). Disclosure: Dr. Von Glehn Silva has nothing to disclose. Dr. Jarius has received research support from Bayer Healthcare and Merck Serono. Dr. Penalva de Oliveira has received personal compensation for activities with Abbott, Bristol Myers Squibb and GlaxoSmithKline. Dr. Brandao has nothing to disclose. Dr. Farias has nothing to disclose. Dr. Damasceno has nothing to disclose. Dr. Casseb has nothing to disclose. Dr. Moraes has nothing to disclose. Dr. Longhini has nothing to disclose. Dr. Wandinger has received personal compensation for activities with Euroimmun AG as an employee. Dr. Damasceno has nothing to disclose. Dr. Wildemann has received personal compensation for activities with Merck-Serono and Teva/Sanofi Aventis. Dr. Wildemann has received research support from Novartis Pharma GmbH and the German Federal Ministry of Education and Research. Dr. Santos has nothing to disclose." @default.
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• W90202938 date "2013-02-12" @default.
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• W90202938 title "Aquaporin-4 Antibodies Are Not Related to HTLV-1 Associated Myelopathy (P02.140)" @default.
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