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- W90203921 endingPage "357" @default.
- W90203921 startingPage "333" @default.
- W90203921 abstract "Publisher Summary The group of transcription factors named signal transducers and activators of transcription (STATs) have been identified as a part of a signaling pathway that initiates in the plasma membrane but quickly translocates to the cytoplasm and to the nucleus to activate transcription of target genes. Steroid hormone receptors (SHRs) are members of a family of ligand-activated transcription factors that regulate many biological processes, including metabolism, reproduction, and development. The SHRs include androgen receptor (AR), estrogen receptor (ER), glucocorticoid receptor (GR), and progesterone receptor (PR). Several groups have demonstrated a role of activated STAT3 in the proliferation and survival of prostate cancer cells by a mechanism that involves the androgen receptor (AR). The constitutively active form of STAT3 stimulates transcriptional activity of SHRs in a hormone-dependent manner. Active STAT3 can act synergistically with other coactivators to stimulate SHRs transcriptional activity. While STAT3 did not affect specificity of AR to other steroid hormones rather than androgen, or binding of AR to other HREs, STAT3 significantly increased the sensitivity of AR to androgen. These results can shed more light on the mechanism by which SHRs (AR in particular) regulate gene expression. Constitutively active STAT3 enhances transcriptional activity of SHRs, including AR, GR, PR, and ER, in a comparable extent to the stimulation elicited by other coactivators and, even more, in a synergistic manner to these other coactivators." @default.
- W90203921 created "2016-06-24" @default.
- W90203921 creator A5021846966 @default.
- W90203921 creator A5048369552 @default.
- W90203921 date "2005-01-01" @default.
- W90203921 modified "2023-09-23" @default.
- W90203921 title "STAT3 and Transactivation of Steroid Hormone Receptors" @default.
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