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- W90218281 abstract "The cardiac interstitium is a diverse system of extracellular matrix (EMC) components organized into a stress-tolerant three-dimensional network that interconnects the cellular components of the heart. At the molecular level, the ECM is attached to cells primarily via integrin receptors which in turn connect to the cytoskeleton. This ECM-integrin-cytoskeletal linkage is thought to be important in transducing extracellular mechanical forces to the cells. While it is generally believed that integrins are involved in the initial detection of mechanical signals by cells, the subsequent steps in the responses of cells to these signals have not been well elucidated. In this study, we demonstrate that stretch of cardiac fibroblasts results in a rapid but transient increase in MAPK phosphorylation. Blocking this pathway with a specific phamacological inhibitor resulted in a complete attenuation of the normally observed stretch-induced cytoskeletal and cellular realignment. The results support the notion that the MAPK pathway is involved in transducing mechanical stretch signals." @default.
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- W90218281 date "2000-01-01" @default.
- W90218281 modified "2023-09-27" @default.
- W90218281 title "Cardiac Cell-ECM Interactions: A Possible Site for Mechanical Signaling" @default.
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- W90218281 doi "https://doi.org/10.1007/978-1-4615-4423-4_11" @default.
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