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- W90334080 abstract "Reduced tissue oxygenation stabilizes the alpha-subunit of the transcription factor hypoxia-inducible factor-1 (HIF-1). This leads to the induction of a number of hypoxia responsive genes. One of the best known HIF-1 targets is erythropoietin that exerts neuroprotective effects on ischemia-related injury in the brain. Thus, pre-exposure to low environmental oxygen concentrations might be exploited as a preconditioning procedure to protect tissues against a variety of harmful conditions. We present recent work on neuroprotection of retinal photoreceptors induced by hypoxic preconditioning or by systemically elevated levels of Epo in mouse plasma." @default.
- W90334080 created "2016-06-24" @default.
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- W90334080 date "2006-01-01" @default.
- W90334080 modified "2023-10-01" @default.
- W90334080 title "Hypoxic Preconditioning and Erythropoietin Protect Retinal Neurons from Degeneration" @default.
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- W90334080 doi "https://doi.org/10.1007/978-0-387-34817-9_11" @default.
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