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- W903917906 endingPage "48" @default.
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- W903917906 abstract "There has been the identification of two native hexokinases in baker's yeast, the resolution of the question of the molecular weight and subunit structure of each, the delineation of the chemical and physical changes accompanying proteolytic modification of the enzyme, and new knowledge on the mechanism of the reaction, including substrate binding studies as well as kinetic studies on both the phosphorylating and the hydrolytic functions. There have been studies bearing on the question of a phosphoenzyme intermediate in the reaction; discovery of regulatory effects on one of the isoenzymes by metabolites those serve as activators or inhibitors; the finding of slow responses to addition of substrates, activators, or inhibitors; and the initiation of X-ray crystallographic studies. In mammalian hexokinases, there has been the identification of several isoenzymes with different distribution in different tissues; the discovery of factors those determine the distribution of enzyme between soluble and mitochondria-bound forms and exert regulatory effects on activity; the purification of solubilized enzymes, in some cases to homogeneity; the establishment of the molecular weight of peptide chain; studies on enzyme mechanism; and studies on factors regulating activity of the enzymes. This chapter describes these advances in the study of yeast and mammalian enzymes, including other hexokinases and enzyme systems for sugar phosphorylation. A method for the preparation of the native hexokinase isoenzymes by batchwise elution from diethylaminoethyl (DEAE)-cellulose is described in the chapter. The chapter presents the molecular weight and subunit structure in nondenaturing and denaturing solvents, and the chemical comparison and nature of the native isoenzymes and proteolytic modification. It discusses the kinetic studies of the yeast hexokinase reaction, the ATPase reaction of yeast hexokinase, and the equilibrium measurements of enzyme-substrate interaction." @default.
- W903917906 created "2016-06-24" @default.
- W903917906 creator A5088282668 @default.
- W903917906 date "1973-01-01" @default.
- W903917906 modified "2023-10-15" @default.
- W903917906 title "1 The Hexokinases" @default.
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