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• W90395005 startingPage "705" @default.
• W90395005 abstract "Abundant extracellular lipid deposits are associated with cell necrosis and tissue weakening in the core region of human atherosclerotic fibrous plaques. The ultrastructural morphology of the core region, previously undefined because of lipid extraction artifacts, was studied with the aid of new osmium-thiocarbohydrazide-osmium and osmium-tannic acid-paraphenylenediamine sequences for tissue processing. Small droplets of neutral lipid (30 to 400 nm profile diameter) and lipid vesicles with aqueous centers accounted for more than 90% of the area occupied by lipid-rich structures in the core region. No foam cells were present. Cholesterol crystals, lipid droplets of a size similar to those in foam cells (0.4 to 6 mu), and larger neutral lipid deposits (greater than 6 mu) together occupied less than 10% of the total area of lipid structures. Abundant lipid vesicles were associated with the nearby presence of cholesterol crystals, whereas small lipid droplets were predominant in areas without crystals. Many droplets had surface defects in the form of pits and vesicular blebs. These morphologic findings are explained most concisely by postulating direct accumulation of extracellular lipid from interstitial lipoproteins as a major process in core region formation. Moreover, a dynamic state of ongoing physical/metabolic transformation of extracellular lipid deposits is suggested." @default.
• W90395005 created "2016-06-24" @default.
• W90395005 creator A5008726377 @default.
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• W90395005 date "1989-03-01" @default.
• W90395005 modified "2023-09-26" @default.
• W90395005 title "The lipid-rich core region of human atherosclerotic fibrous plaques. Prevalence of small lipid droplets and vesicles by electron microscopy." @default.
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• W90395005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1879512" @default.
• W90395005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2646938" @default.
• W90395005 hasPublicationYear "1989" @default.
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