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- W9040617 abstract "Correct gene expression is a conditio sine qua for proper development of the heart; development of cardiovascular disease is often due to deregulation of gene expression. Epigenetics is a major mechanism controlling gene regulation in eukaryotic cells and consists in modulation of gene expression patterns without modifying the actual DNA sequence. The alteration of epigenetic mechanisms has been found to be involved in the etiology of several diseases, such as cancer, diabetes, and neuronal disorders (e.g. Rett syndrome and Parkinson’s disease); epigenetics has also been linked to heart development and disease. In particular, histone acetylation and chromatin remodeling are two important mechanisms in both activation of cardiac-specific genes and repression of non-cardiac ones during heart development, and in the re-programming that underlies cardiac hypertrophy. This chapter gives an overview of the role of epigenetics in heart development and in two important cardiovascular pathologies – heart failure and atherosclerosis." @default.
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- W9040617 date "2012-01-01" @default.
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- W9040617 title "Epigenetics in Cardiovascular Biology" @default.
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