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- W90435664 abstract "It is well known that acute brain swelling is caused by extreme vasoparalysis due to loss of autoregulation. Although the basic mechanism of cerebral autoregulation is still controversial, metabolic, chemical, myogenic and neuronal factors have been considered and examined experimentally. The hypothalamus is stated by some workers as a major neuronal aggregate participating in autoregulation of the cerebral circulation. In the present experimental study, neuronal components rostral and caudal to the hypothalamus were examined to determine if they were involved in the autoregulation mechanism. Topical application of epinephrine to either the sigmoid, orbital, or cingulate gyrus or cerebellar cortex of a cat caused the systemic blood pressure rise temporally, but when application was performed to other cortices, no change in blood pressure was observed. This phenomenon disappeared when the hypothalamus was destroyed. With the model of acute swelling caused by ischemia and the balloon compression method, application of epinephrine to the sigmoid gyrus caused a considerable decrease of intracranial pressure concomitant with an increase in cerebral blood flow. However in an animal with acute brain swelling with destruction of the hypothalamus or transection of the spinal cord at the Th2 level, no improvement of cerebral vascular tonicity was observed. It was suggested that the neuronal pathway, the cerebral cortices and the cerebellar cortex converging on the hypothalamus and descending to the spinal cord at Th2 level play an important role in cerebral vascular tonicity." @default.
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- W90435664 date "1980-01-01" @default.
- W90435664 modified "2023-10-18" @default.
- W90435664 title "Experimental Studies on the Mechanism of Acute Brain Swelling" @default.
- W90435664 doi "https://doi.org/10.2176/nmc.20.363" @default.
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