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- W9045364 abstract "目的：探讨瘦素、胰岛素及IGF-2对滋养层细胞中PKB和P70S6K蛋白表达的影响是否与PI3K/PKB/mTOR信号途径存在联系。方法：应用Western blot检测瘦素、胰岛素及IGF-2作用后滋养层细胞中PKB和P70S6K蛋白的表达,以及分别加入PI3K的特异性抑制剂LY294002和mTOR的特异性抑制剂雷帕霉素后对PKB和P70S6K蛋白表达的影响。结果：瘦素、胰岛素及IGF-2刺激组滋养层细胞中PKB和P70S6K蛋白表达与对照组相比明显增加（P〈0.05）。瘦素、胰岛素及IGF-2刺激组分别加入LY294002和雷帕霉素,PKB和P70S6K蛋白表达均明显降低（P〈0.05）。结论：瘦素、胰岛素及IGF-2可能通过PI3K/PKB/mTOR信号通路促进滋养层细胞中PKB和P70S6K蛋白表达。" @default.
- W9045364 created "2016-06-24" @default.
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- W9045364 date "2010-01-01" @default.
- W9045364 modified "2023-09-23" @default.
- W9045364 title "瘦素、胰岛素及IGF-2影响滋养层细胞中PKB和P70S6K蛋白表达的机制" @default.
- W9045364 hasPublicationYear "2010" @default.
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