FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W904764605> ?p ?o ?g. }

• W904764605 endingPage "831" @default.
• W904764605 startingPage "822" @default.
• W904764605 abstract "Functional abnormalities in fear circuitry are likely to underlie the pathophysiology of pediatric posttraumatic stress disorder (PTSD), but the few studies to date have yielded conflicting findings. Furthermore, network level functional connectivity and age-related disruptions in fear circuitry have not been thoroughly explored. In a cross-sectional design, 24 healthy and 24 medication-free youth with severe PTSD completed an event-related emotion-processing task during functional MRI. Youth viewed threat and neutral images, half of which were paired with a neutral male face. Group- and age-related differences in brain activation were examined in the medial prefrontal cortex (mPFC), amygdala, and hippocampus. Amygdala functional connectivity was examined using a seed-based approach. PTSD youth showed hyperactivation of the dorsal anterior cingulate cortex (dACC) to threat images. In the dorsomedial PFC (dmPFC), age positively predicted activation in healthy youth but negatively predicted activation in PTSD youth. In the amygdala functional connectivity analysis, PTSD youth showed decreased amygdala-mPFC connectivity to threat images. Furthermore, age positively predicted amygdala-vmPFC connectivity in healthy youth, but negatively predicted connectivity in PTSD youth. Finally, dmPFC activation and amygdala-mPFC connectivity were inversely related to PTSD severity. Pediatric PTSD involves abnormal functional activation and connectivity in fear circuitry. Specifically, dACC hyperactivation is consistent with abnormal promotion of fear responses, whereas reduced amygdala-mPFC connectivity suggests impaired regulation of amygdala responses to threat. Importantly, age-dependent decreases in dmPFC activation and amygdala-vmPFC connectivity may indicate abnormal developmental processes in key emotion pathways in pediatric PTSD." @default.
• W904764605 created "2016-06-24" @default.
• W904764605 creator A5008589773 @default.
• W904764605 creator A5074101636 @default.
• W904764605 date "2015-07-14" @default.
• W904764605 modified "2023-10-18" @default.
• W904764605 title "Prefrontal–Amygdala Dysregulation to Threat in Pediatric Posttraumatic Stress Disorder" @default.
• W904764605 cites W1521312467 @default.
• W904764605 cites W1976310982 @default.
• W904764605 cites W1977502547 @default.
• W904764605 cites W1982578342 @default.
• W904764605 cites W1983302342 @default.
• W904764605 cites W1988875934 @default.
• W904764605 cites W1990902716 @default.
• W904764605 cites W1994589492 @default.
• W904764605 cites W1995717554 @default.
• W904764605 cites W1996446802 @default.
• W904764605 cites W2002801119 @default.
• W904764605 cites W2003598308 @default.
• W904764605 cites W2006096283 @default.
• W904764605 cites W2016117011 @default.
• W904764605 cites W2019064852 @default.
• W904764605 cites W2024923484 @default.
• W904764605 cites W2026836897 @default.
• W904764605 cites W2032022668 @default.
• W904764605 cites W2044740696 @default.
• W904764605 cites W2046845602 @default.
• W904764605 cites W2050618347 @default.
• W904764605 cites W2057962659 @default.
• W904764605 cites W2068118815 @default.
• W904764605 cites W2086354265 @default.
• W904764605 cites W2090245491 @default.
• W904764605 cites W2095811485 @default.
• W904764605 cites W2100880539 @default.
• W904764605 cites W2103558642 @default.
• W904764605 cites W2103881507 @default.
• W904764605 cites W2105263523 @default.
• W904764605 cites W2110431345 @default.
• W904764605 cites W2110747672 @default.
• W904764605 cites W2117140276 @default.
• W904764605 cites W2120731293 @default.
• W904764605 cites W2127436676 @default.
• W904764605 cites W2133664593 @default.
• W904764605 cites W2141460037 @default.
• W904764605 cites W2143337872 @default.
• W904764605 cites W2143859454 @default.
• W904764605 cites W2148997797 @default.
• W904764605 cites W2150693380 @default.
• W904764605 cites W2152292563 @default.
• W904764605 cites W2155444575 @default.
• W904764605 cites W2159812249 @default.
• W904764605 cites W2160028381 @default.
• W904764605 cites W2166088151 @default.
• W904764605 cites W2167216405 @default.
• W904764605 cites W2169366712 @default.
• W904764605 doi "https://doi.org/10.1038/npp.2015.209" @default.
• W904764605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4707828" @default.
• W904764605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26171717" @default.
• W904764605 hasPublicationYear "2015" @default.
• W904764605 type Work @default.
• W904764605 sameAs 904764605 @default.
• W904764605 citedByCount "103" @default.
• W904764605 countsByYear W9047646052016 @default.
• W904764605 countsByYear W9047646052017 @default.
• W904764605 countsByYear W9047646052018 @default.
• W904764605 countsByYear W9047646052019 @default.
• W904764605 countsByYear W9047646052020 @default.
• W904764605 countsByYear W9047646052021 @default.
• W904764605 countsByYear W9047646052022 @default.
• W904764605 countsByYear W9047646052023 @default.
• W904764605 crossrefType "journal-article" @default.
• W904764605 hasAuthorship W904764605A5008589773 @default.
• W904764605 hasAuthorship W904764605A5074101636 @default.
• W904764605 hasBestOaLocation W9047646051 @default.
• W904764605 hasConcept C126322002 @default.
• W904764605 hasConcept C15744967 @default.
• W904764605 hasConcept C169760540 @default.
• W904764605 hasConcept C169900460 @default.
• W904764605 hasConcept C2778366672 @default.
• W904764605 hasConcept C2778627534 @default.
• W904764605 hasConcept C2779144063 @default.
• W904764605 hasConcept C2779226451 @default.
• W904764605 hasConcept C2781161787 @default.
• W904764605 hasConcept C2781195155 @default.
• W904764605 hasConcept C71924100 @default.
• W904764605 hasConceptScore W904764605C126322002 @default.
• W904764605 hasConceptScore W904764605C15744967 @default.
• W904764605 hasConceptScore W904764605C169760540 @default.
• W904764605 hasConceptScore W904764605C169900460 @default.
• W904764605 hasConceptScore W904764605C2778366672 @default.
• W904764605 hasConceptScore W904764605C2778627534 @default.
• W904764605 hasConceptScore W904764605C2779144063 @default.
• W904764605 hasConceptScore W904764605C2779226451 @default.
• W904764605 hasConceptScore W904764605C2781161787 @default.
• W904764605 hasConceptScore W904764605C2781195155 @default.
• W904764605 hasConceptScore W904764605C71924100 @default.
• W904764605 hasIssue "3" @default.
• W904764605 hasLocation W9047646051 @default.

• next