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Matches in SemOpenAlex for { <https://semopenalex.org/work/W904802307> ?p ?o ?g. }

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• W904802307 startingPage "9685" @default.
• W904802307 abstract "Galectin-3 binding protein (Gal-3BP) is a large hyperglycosylated protein that acts as a ligand for several galectins through glycan-dependent interactions. Gal-3BP can induce galectin-mediated tumor cell aggregation to increase the survival of cancer cells in the bloodstream during the metastatic process. However, the galectin interacting with Gal-3BP and its binding specificity has not been identified and structurally elucidated, mainly due to the limitation of mass spectrometry in glycan sequencing. To understand the role of Gal-3BP, we here used liquid chromatography–mass spectrometry combined with specific exoglycosidase reactions to determine the sequences of N-glycans on Gal-3BP from MCF-7 and MDA-MB-231 cells, especially the sequences with terminal sialylation and fucosylation, and addition of LacNAc repeat structures. The N-glycans from both strains are complex type with terminal α2,3-sialidic acid and core fucose linkages, with additional α1,2- and α1,3 fucose linkages found in MCF-7 cells. Compared with that from MCF-7, the Gal-3BP from MDA-MB-231 cells had fewer tetra-antennary structures, only α1,6-linked core fucoses, and more LacNAc repeat structures; the MDA-MB-231 cells had no surface galectin-3 but used surface galectin-1 for interaction with Gal-3BP to form large oligomers and cell aggregates. This study elucidates the specificity of Gal-3BP interacting with galectin-1 and the role of Gal-3BP in cancer cell aggregation and metastasis." @default.
• W904802307 created "2016-06-24" @default.
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• W904802307 date "2015-07-22" @default.
• W904802307 modified "2023-10-16" @default.
• W904802307 title "Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis" @default.
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• W904802307 doi "https://doi.org/10.1021/jacs.5b04744" @default.
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