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- W90486162 abstract "Aim/Background: The objective of the study was to determine the profile of viral markers of HBV and HCV among asymptomatic individuals with chronic hepatitis B surface antigen (HBsAg). Methods: Seventy one subjects who were chronic HBsAg positive were recruited as cases and thirty three apparently normal individuals who were negative for HBsAg served as controls. Serum anti-HBc (IgM and Total), HBeAg, anti-HBe and HBV-DNA were studied in both cases and controls. HBV DNA where positive were sequenced for genotype determination. Result: Total anti-HBc was the commonest serological marker of HBV, 59 (83.1%) among cases, but was not significantly different from that of the control group in which it occurred in (69.7%), p=0.12, while HBeAg and anti-HCV were found to be low and similar in prevalence in both groups. Anti-HBe was found in 42.3% of cases and in 27.3% of controls, p=0.14. IgM anti-HBc and HBV-DNA were negative among the control group. IgM anti-HBc was present in 21(29.6) of cases. Among cases, HBV-DNA was present in 9 (%) but in low concentration and were all of genotype E. Conclusion: In conclusion, asymptomatic HBV infection is associated with low levels of HBeAg, HBVDNA and anti-HCV, but high levels of total anti-HBc among asymptomatic Nigerians. Occult HBV infection appeared uncommon. Keywords: Hepatitis B virus,Viral load, Hepatitis C co-infection" @default.
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- W90486162 date "2009-01-01" @default.
- W90486162 modified "2023-09-23" @default.
- W90486162 title "Profile of Hepatitis B and Hepatitis C Markers in Asymptomatic Chronic HBV Infection in an Endemic Population" @default.
- W90486162 hasPublicationYear "2009" @default.
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