Matches in SemOpenAlex for { <https://semopenalex.org/work/W90555304> ?p ?o ?g. }
- W90555304 endingPage "88" @default.
- W90555304 startingPage "279" @default.
- W90555304 abstract "Lowering elevated blood pressure (BP) with drug therapy reduces the risk for catastrophic fatal and nonfatal cardiovascular events such as stroke and myocardial infarction. Given the heterogeneity of hypertension as a disease, the marked variability in an individual patient's BP response, and low response rates with monotherapy, expert groups such as the Joint National Committee (JNC) emphasize the value of combination antihypertensive regimens, noting that combinations, usually of different classes, have additive antihypertensive effects. Metoprolol succinate extended-release tablet is a beta-1 (cardio-selective) adrenoceptor-blocking agent formulated to provide controlled and predictable release of metoprolol. Hydrochlorothiazide (HCT) is a well-established diuretic and antihypertensive agent, which promotes natruresis by acting on the distal renal tubule. The pharmacokinetics, efficacy, and safety/tolerability of the antihypertensive combination tablet, metoprolol extended release hydrochlorothiazide, essentially reflect the well-described independent characteristics of each of the component agents. Not only is the combination product more effective than monotherapy with the individual components but the combination product allows a low-dose multidrug regimen as an alternative to high-dose monotherapy, thereby, minimizing the likelihood of dose-related side-effects." @default.
- W90555304 created "2016-06-24" @default.
- W90555304 creator A5003129000 @default.
- W90555304 creator A5013087961 @default.
- W90555304 date "2007-01-01" @default.
- W90555304 modified "2023-09-23" @default.
- W90555304 title "Metoprolol succinate extended release/hydrochlorothiazide combination tablets." @default.
- W90555304 cites W117010490 @default.
- W90555304 cites W1465551735 @default.
- W90555304 cites W1497461844 @default.
- W90555304 cites W1968880305 @default.
- W90555304 cites W1977607782 @default.
- W90555304 cites W2010746771 @default.
- W90555304 cites W2013354239 @default.
- W90555304 cites W2016287889 @default.
- W90555304 cites W2016991967 @default.
- W90555304 cites W2018337434 @default.
- W90555304 cites W2019428374 @default.
- W90555304 cites W2024380309 @default.
- W90555304 cites W2028316425 @default.
- W90555304 cites W2033184572 @default.
- W90555304 cites W2033444229 @default.
- W90555304 cites W2045203451 @default.
- W90555304 cites W2066655930 @default.
- W90555304 cites W2068908293 @default.
- W90555304 cites W2071430338 @default.
- W90555304 cites W2087140323 @default.
- W90555304 cites W2098869086 @default.
- W90555304 cites W2111430134 @default.
- W90555304 cites W2113176678 @default.
- W90555304 cites W2119369921 @default.
- W90555304 cites W2139805666 @default.
- W90555304 cites W2156121263 @default.
- W90555304 cites W2409334517 @default.
- W90555304 cites W2475261460 @default.
- W90555304 cites W2562329777 @default.
- W90555304 cites W4246169631 @default.
- W90555304 cites W4302434154 @default.
- W90555304 cites W7687383 @default.
- W90555304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2293963" @default.
- W90555304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17703635" @default.
- W90555304 hasPublicationYear "2007" @default.
- W90555304 type Work @default.
- W90555304 sameAs 90555304 @default.
- W90555304 citedByCount "4" @default.
- W90555304 countsByYear W905553042014 @default.
- W90555304 countsByYear W905553042015 @default.
- W90555304 crossrefType "journal-article" @default.
- W90555304 hasAuthorship W90555304A5003129000 @default.
- W90555304 hasAuthorship W90555304A5013087961 @default.
- W90555304 hasConcept C126322002 @default.
- W90555304 hasConcept C197934379 @default.
- W90555304 hasConcept C2776623344 @default.
- W90555304 hasConcept C2776999253 @default.
- W90555304 hasConcept C2778375690 @default.
- W90555304 hasConcept C2779918671 @default.
- W90555304 hasConcept C2780361556 @default.
- W90555304 hasConcept C2781280847 @default.
- W90555304 hasConcept C2781413609 @default.
- W90555304 hasConcept C71924100 @default.
- W90555304 hasConcept C84393581 @default.
- W90555304 hasConcept C98274493 @default.
- W90555304 hasConceptScore W90555304C126322002 @default.
- W90555304 hasConceptScore W90555304C197934379 @default.
- W90555304 hasConceptScore W90555304C2776623344 @default.
- W90555304 hasConceptScore W90555304C2776999253 @default.
- W90555304 hasConceptScore W90555304C2778375690 @default.
- W90555304 hasConceptScore W90555304C2779918671 @default.
- W90555304 hasConceptScore W90555304C2780361556 @default.
- W90555304 hasConceptScore W90555304C2781280847 @default.
- W90555304 hasConceptScore W90555304C2781413609 @default.
- W90555304 hasConceptScore W90555304C71924100 @default.
- W90555304 hasConceptScore W90555304C84393581 @default.
- W90555304 hasConceptScore W90555304C98274493 @default.
- W90555304 hasIssue "3" @default.
- W90555304 hasLocation W905553041 @default.
- W90555304 hasOpenAccess W90555304 @default.
- W90555304 hasPrimaryLocation W905553041 @default.
- W90555304 hasRelatedWork W1981821168 @default.
- W90555304 hasRelatedWork W1987574066 @default.
- W90555304 hasRelatedWork W1988500064 @default.
- W90555304 hasRelatedWork W1989898358 @default.
- W90555304 hasRelatedWork W1997187326 @default.
- W90555304 hasRelatedWork W2004812887 @default.
- W90555304 hasRelatedWork W2009040815 @default.
- W90555304 hasRelatedWork W2018318830 @default.
- W90555304 hasRelatedWork W2038076091 @default.
- W90555304 hasRelatedWork W2097565561 @default.
- W90555304 hasRelatedWork W2100328319 @default.
- W90555304 hasRelatedWork W2103927357 @default.
- W90555304 hasRelatedWork W2126199599 @default.
- W90555304 hasRelatedWork W2146283415 @default.
- W90555304 hasRelatedWork W2303109384 @default.
- W90555304 hasRelatedWork W2408372455 @default.
- W90555304 hasRelatedWork W2424675252 @default.
- W90555304 hasRelatedWork W2467083560 @default.
- W90555304 hasRelatedWork W60592839 @default.
- W90555304 hasRelatedWork W61614742 @default.