Matches in SemOpenAlex for { <https://semopenalex.org/work/W90558440> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W90558440 endingPage "16" @default.
- W90558440 startingPage "11" @default.
- W90558440 abstract "Despite the 42 years that have elapsed since the isolation of the varicella-zoster virus (VZV), our understanding of the immunology of chickenpox remains incomplete. Major hurdles to a fuller understanding of the immunological events that take place on contact with VZV have been the absence of a generally accepted animal model 1 and the incomplete nature of the immunity induced. 2 The absence of an animal model has led to the extrapolation from related models. While deriving a plausible model of pathogenesis, 3 related models have not proven useful in analysing the immune response to VZV. Incomplete immunity in 15% of the population is associated with the occurrence of zoster in individuals previously infected with the VZV and the much rarer occurrence of chickenpox in individuals with documented immunity. 4' 5 An understanding of the relative importance of the humoral versus the cellular immune system has been both informed and complicated by a number of 'experiments of nature'. The importance of the cellular immune system is highlighted by the relatively benign nature of clinical chickenpox in children with 'pure' humoral defects such as agammaglobulinaemia, contrasted with the life-threatening nature of the illness in individuals with compromised cell-mediated immunity. 6 Antibodies alone cannot prevent chickenpox or zoster, and reinfection with VZV has been documented in antibody-positive individuals. In contrast, anti-VZV antibodies derived from immune donors and contained in zoster immune globulin are able to modify the natural history of VZV infection and even prevent clinical infection when given to susceptible VZV contacts. The lack of clarity regarding the immunology of VZV infection has been further hampered by the absence of a 'gold standard' in vitro correlate of" @default.
- W90558440 created "2016-06-24" @default.
- W90558440 creator A5015087698 @default.
- W90558440 date "1998-01-01" @default.
- W90558440 modified "2023-09-28" @default.
- W90558440 title "The immunology of chickenpox" @default.
- W90558440 cites W1495829907 @default.
- W90558440 cites W1587789887 @default.
- W90558440 cites W1675789952 @default.
- W90558440 cites W1854114816 @default.
- W90558440 cites W1869339365 @default.
- W90558440 cites W1897410289 @default.
- W90558440 cites W1966698640 @default.
- W90558440 cites W1967910934 @default.
- W90558440 cites W1984522203 @default.
- W90558440 cites W1984568096 @default.
- W90558440 cites W1984626307 @default.
- W90558440 cites W1998736210 @default.
- W90558440 cites W2032945876 @default.
- W90558440 cites W2035179548 @default.
- W90558440 cites W2042976847 @default.
- W90558440 cites W2044845416 @default.
- W90558440 cites W2046013402 @default.
- W90558440 cites W2047469480 @default.
- W90558440 cites W2055315293 @default.
- W90558440 cites W2058939976 @default.
- W90558440 cites W2059270461 @default.
- W90558440 cites W2059625645 @default.
- W90558440 cites W2061739175 @default.
- W90558440 cites W2063953886 @default.
- W90558440 cites W2068885329 @default.
- W90558440 cites W2072177953 @default.
- W90558440 cites W2072317513 @default.
- W90558440 cites W2072388246 @default.
- W90558440 cites W2072589914 @default.
- W90558440 cites W2073801065 @default.
- W90558440 cites W2081527399 @default.
- W90558440 cites W2082443813 @default.
- W90558440 cites W2096242864 @default.
- W90558440 cites W2106734808 @default.
- W90558440 cites W2113152984 @default.
- W90558440 cites W2118383642 @default.
- W90558440 cites W2135703854 @default.
- W90558440 cites W2140898723 @default.
- W90558440 cites W2150538593 @default.
- W90558440 cites W2157832836 @default.
- W90558440 cites W2160054077 @default.
- W90558440 cites W2314176578 @default.
- W90558440 cites W2337596941 @default.
- W90558440 doi "https://doi.org/10.1016/s0163-4453(98)80150-3" @default.
- W90558440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9514103" @default.
- W90558440 hasPublicationYear "1998" @default.
- W90558440 type Work @default.
- W90558440 sameAs 90558440 @default.
- W90558440 citedByCount "7" @default.
- W90558440 countsByYear W905584402015 @default.
- W90558440 countsByYear W905584402016 @default.
- W90558440 crossrefType "journal-article" @default.
- W90558440 hasAuthorship W90558440A5015087698 @default.
- W90558440 hasConcept C159047783 @default.
- W90558440 hasConcept C203014093 @default.
- W90558440 hasConcept C2522874641 @default.
- W90558440 hasConcept C2776334287 @default.
- W90558440 hasConcept C2780473352 @default.
- W90558440 hasConcept C2780801004 @default.
- W90558440 hasConcept C2908772859 @default.
- W90558440 hasConcept C71924100 @default.
- W90558440 hasConcept C8891405 @default.
- W90558440 hasConceptScore W90558440C159047783 @default.
- W90558440 hasConceptScore W90558440C203014093 @default.
- W90558440 hasConceptScore W90558440C2522874641 @default.
- W90558440 hasConceptScore W90558440C2776334287 @default.
- W90558440 hasConceptScore W90558440C2780473352 @default.
- W90558440 hasConceptScore W90558440C2780801004 @default.
- W90558440 hasConceptScore W90558440C2908772859 @default.
- W90558440 hasConceptScore W90558440C71924100 @default.
- W90558440 hasConceptScore W90558440C8891405 @default.
- W90558440 hasLocation W905584401 @default.
- W90558440 hasLocation W905584402 @default.
- W90558440 hasOpenAccess W90558440 @default.
- W90558440 hasPrimaryLocation W905584401 @default.
- W90558440 hasRelatedWork W1953041445 @default.
- W90558440 hasRelatedWork W2037280289 @default.
- W90558440 hasRelatedWork W2049179889 @default.
- W90558440 hasRelatedWork W2073089856 @default.
- W90558440 hasRelatedWork W2127642522 @default.
- W90558440 hasRelatedWork W2419647735 @default.
- W90558440 hasRelatedWork W2997817617 @default.
- W90558440 hasRelatedWork W3000126929 @default.
- W90558440 hasRelatedWork W4256386387 @default.
- W90558440 hasRelatedWork W2007503004 @default.
- W90558440 hasVolume "36" @default.
- W90558440 isParatext "false" @default.
- W90558440 isRetracted "false" @default.
- W90558440 magId "90558440" @default.
- W90558440 workType "article" @default.