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- W9058518 abstract "In rat lenses, glutamine (GLN), not glutamate (GLU), from the surrounding fluids is the primary source of GLU utilized by several metabolic pathways. To study lenticular amino acid metabolism in a primate, fresh lenses from young (2-3 yr) rhesus monkeys (Macaca mulatta) were incubated at 37/sup 0/C for 3, 6, or 24 hr in balanced salt medium containing 5 mM of amino-labeled /sup 15/N-GLN or /sup 15/N-GLU. The % enrichment of /sup 15/N in several free amino acids was determined by GCMS. GLN entered the monkey lenses more rapidly than GLU, but, in contrast to rat lenses, /sup 15/N-GLN did not more rapidly label other amino acids. The % of /sup 15/N in the (GLN + GLU) pool of the monkey lenses in /sup 15/N-GLN reached 20, 35, and 60% at 3, 6, and 24 hr respectively, compared with 10, 20, and 40% in the lenses in /sup 15/N-GLU. However, in monkey lenses incubated 24 hr with /sup 15/N-GLN, the /sup 15/N in alanine, serine, proline, and (aspartate + asparagine) was only 35, 6, 7, and 30% respectively, compared with 50, 10, 7, and 50% in monkey lenses with /sup 15/N-GLU. Compared with rat lenses, monkey lenses showed slower transport,more » deamidation, and metabolism of GLN, and less serine, proline, and glycine synthesis. Also, part of the GLU in monkey lenses appeared to be in a slowly transaminating pool. Species differences should be considered when rats are used as a model to study changes in human lenses during aging and cataractogenesis.« less" @default.
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- W9058518 date "1986-05-01" @default.
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- W9058518 title "Metabolism of glutamine and glutamate in monkey lenses" @default.
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