Matches in SemOpenAlex for { <https://semopenalex.org/work/W9058992> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W9058992 endingPage "183" @default.
- W9058992 startingPage "175" @default.
- W9058992 abstract "The term ‘matricellular’ was coined to identify a group of proteins that are secreted and function in the extracellular matrix, but do not play a structural role as an integral component of a physical entity such as a fiber or basement membrane. Instead, matricellular proteins primarily serve to modulate cell function. These functions are achieved in part by interaction with a variety of cell-surface receptors, with the resulting engagement of signal transduction pathways. Matricellular proteins are also capable of interacting with structural matrix proteins, such as collagens and fibronectin, and with a number of bioactive proteins, that is, cytokines, growth factors, and proteases. As a consequence, these bioactive molecules can either be sequestered in the matrix, presented to their appropriate receptors, or in the case of proteases, inhibited by direct binding or cleared from the pericellular environment by formation of protein–enzyme complexes that are recognized by a scavenger receptor. It should be noted, however, that the distinction between matricellular and structural matrix proteins is not sharp, since structural proteins such as collagens, laminins, and fibronectin also influence cell function by interaction with cell-surface receptors, and they also bind bioactive proteins. The classification of proteins as matricellular is based on similarity of mode of action rather than on homology in amino acid sequence and three-dimensional structure. Thus, the thrombospondins, SPARC family members, tenascins, CCN proteins, and osteopontin, the core group of matricellular proteins considered in this chapter, are structurally unrelated. The partial dependence of the function of matricellular proteins on the proteins with which they interact gives rise to the characterization of their function as contextual. The relevance of these proteins to the biochemistry and physiology of the lung will therefore depend to a large extent on the co-expression of interacting proteins. Matricellular proteins are frequently expressed in pulmonary fibrosis and in neoplasms of the lung, and early evidence supports the ability of these proteins to influence the progress of these disorders." @default.
- W9058992 created "2016-06-24" @default.
- W9058992 creator A5043009176 @default.
- W9058992 date "2006-01-01" @default.
- W9058992 modified "2023-09-26" @default.
- W9058992 title "EXTRACELLULAR MATRIX | Matricellular Proteins" @default.
- W9058992 cites W1974307668 @default.
- W9058992 cites W1975994080 @default.
- W9058992 cites W1980438007 @default.
- W9058992 cites W1982066003 @default.
- W9058992 cites W1990526837 @default.
- W9058992 cites W2050037284 @default.
- W9058992 cites W2050577046 @default.
- W9058992 cites W2061223357 @default.
- W9058992 cites W2069879634 @default.
- W9058992 cites W2083544543 @default.
- W9058992 cites W2101619182 @default.
- W9058992 cites W2102786937 @default.
- W9058992 cites W2112417973 @default.
- W9058992 cites W2132943628 @default.
- W9058992 cites W2144840590 @default.
- W9058992 cites W2150989762 @default.
- W9058992 doi "https://doi.org/10.1016/b0-12-370879-6/00148-4" @default.
- W9058992 hasPublicationYear "2006" @default.
- W9058992 type Work @default.
- W9058992 sameAs 9058992 @default.
- W9058992 citedByCount "0" @default.
- W9058992 crossrefType "book-chapter" @default.
- W9058992 hasAuthorship W9058992A5043009176 @default.
- W9058992 hasConcept C170493617 @default.
- W9058992 hasConcept C181199279 @default.
- W9058992 hasConcept C182220744 @default.
- W9058992 hasConcept C185592680 @default.
- W9058992 hasConcept C189165786 @default.
- W9058992 hasConcept C197462201 @default.
- W9058992 hasConcept C2775893135 @default.
- W9058992 hasConcept C2779814568 @default.
- W9058992 hasConcept C55493867 @default.
- W9058992 hasConcept C86492073 @default.
- W9058992 hasConcept C86803240 @default.
- W9058992 hasConcept C95444343 @default.
- W9058992 hasConceptScore W9058992C170493617 @default.
- W9058992 hasConceptScore W9058992C181199279 @default.
- W9058992 hasConceptScore W9058992C182220744 @default.
- W9058992 hasConceptScore W9058992C185592680 @default.
- W9058992 hasConceptScore W9058992C189165786 @default.
- W9058992 hasConceptScore W9058992C197462201 @default.
- W9058992 hasConceptScore W9058992C2775893135 @default.
- W9058992 hasConceptScore W9058992C2779814568 @default.
- W9058992 hasConceptScore W9058992C55493867 @default.
- W9058992 hasConceptScore W9058992C86492073 @default.
- W9058992 hasConceptScore W9058992C86803240 @default.
- W9058992 hasConceptScore W9058992C95444343 @default.
- W9058992 hasLocation W90589921 @default.
- W9058992 hasOpenAccess W9058992 @default.
- W9058992 hasPrimaryLocation W90589921 @default.
- W9058992 hasRelatedWork W1970918169 @default.
- W9058992 hasRelatedWork W1995698795 @default.
- W9058992 hasRelatedWork W2034939167 @default.
- W9058992 hasRelatedWork W2064487804 @default.
- W9058992 hasRelatedWork W2065961364 @default.
- W9058992 hasRelatedWork W2102196879 @default.
- W9058992 hasRelatedWork W2106761248 @default.
- W9058992 hasRelatedWork W2115780596 @default.
- W9058992 hasRelatedWork W2362399350 @default.
- W9058992 hasRelatedWork W2399026859 @default.
- W9058992 isParatext "false" @default.
- W9058992 isRetracted "false" @default.
- W9058992 magId "9058992" @default.
- W9058992 workType "book-chapter" @default.