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• W905928685 endingPage "e0133318" @default.
• W905928685 startingPage "e0133318" @default.
• W905928685 abstract "Yersinia pestis, the causative agent of bubonic and pneumonic plague, is typically a zoonotic vector-borne disease of wild rodents. Bacterial biofilm formation in the proventriculus of the flea contributes to chronic infection of fleas and facilitates efficient disease transmission. However prior to biofilm formation, ingested bacteria must survive within the flea midgut, and yet little is known about vector-pathogen interactions that are required for flea gut colonization. Here we establish a Drosophila melanogaster model system to gain insight into Y. pestis colonization of the insect vector. We show that Y. pestis establishes a stable infection in the anterior midgut of fly larvae, and we used this model system to study the roles of genes involved in biofilm production and/or resistance to gut immunity stressors. We find that PhoP and GmhA both contribute to colonization and resistance to antimicrobial peptides in flies, and furthermore, the data suggest biofilm formation may afford protection against antimicrobial peptides. Production of reactive oxygen species in the fly gut, as in fleas, also serves to limit bacterial infection, and OxyR mediates Y. pestis survival in both insect models. Overall, our data establish the fruit fly as an informative model to elucidate the relationship between Y. pestis and its flea vector." @default.
• W905928685 created "2016-06-24" @default.
• W905928685 creator A5000380103 @default.
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• W905928685 creator A5038248024 @default.
• W905928685 creator A5073193118 @default.
• W905928685 creator A5090189767 @default.
• W905928685 date "2015-07-15" @default.
• W905928685 modified "2023-09-26" @default.
• W905928685 title "Resistance to Innate Immunity Contributes to Colonization of the Insect Gut by Yersinia pestis" @default.
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• W905928685 doi "https://doi.org/10.1371/journal.pone.0133318" @default.
• W905928685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4503695" @default.
• W905928685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26177454" @default.
• W905928685 hasPublicationYear "2015" @default.
• W905928685 type Work @default.

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