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- W9060294 abstract "This chapter provides an overview of the cytotoxic macrophages in allograft rejection. It discusses the role of macrophages in syngeneic tumor systems and bactericidal systems. The histological picture of rejection of a skin or tumor allograft shows an infiltrate of mononuclear cells. A high proportion of these cells have been shown to be bone marrow-derived macrophages. The question of the relevance of the macrophage in the effector phase of an allograft rejection is at present still controversial. It has been shown that effector T cells are antigen-reactive cells that are sensitized against foreign transplantation antigens. In vitro, they exert high cytotoxicity as demonstrated by several groups; in vivo T cells need the help of a second cell type provided by the bone marrow. Macrophages are activated and induced to be cytotoxic for tumor target cells by a product of sensitized T cells secreted in the presence of the sensitizing antigen. The macrophage cytotoxicity factor (MCF) binds to syngeneic and allogeneic macrophages, rendering them cytotoxic. Cytotoxic macrophages that have destroyed target cells in tissue culture can be rendered cytotoxic again by incubation with MCF. The same culture of macrophages can destroy several target tumor cell populations." @default.
- W9060294 created "2016-06-24" @default.
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- W9060294 date "1976-01-01" @default.
- W9060294 modified "2023-10-18" @default.
- W9060294 title "Induction of Macrophage-Mediated Cytotoxicity" @default.
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- W9060294 doi "https://doi.org/10.1016/b978-0-12-514550-3.50024-4" @default.
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