Matches in SemOpenAlex for { <https://semopenalex.org/work/W90634587> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W90634587 endingPage "8" @default.
- W90634587 startingPage "83" @default.
- W90634587 abstract "Metronidazole is an antimicrobial, antiprotozoal agent that has been widely used in the treatment of a variety of infections. Some therapeutic indications necessitate prolonged treatment with metronidazole. Peripheral neuropathy is a potential metronidazole-induced toxicity, which has been reported in only a few isolated retrospective studies. This prospective study was designed to determine the toxic profile of metronidazole in patients undergoing long-term treatment with this drug. In the present study, 17 patients of both sexes, aged between 20 and 50 years, with body weights ranging from 46 to 62 kg and who were suffering from various medical ailments were recruited. The patients received 400 mg t.i.d. oral metronidazole in a total dose of 16.8-39.6 g for 2-4 weeks. It was found that patients usually suffered from some of the toxic symptoms of metallic taste, headache and dry mouth and to a lesser extent nausea, glossitis, urticaria, pruritus, urethral burning and dark colored urine. Symptoms were irrespective of sex and directly proportional to duration of therapy. Deep tendon ankle jerks were maximally reduced in four patients and sense of vibration at the level of olecranon and patella was affected in two patients. Distal latency and velocity of the sural and posterior tibial nerves were significantly affected (p < 0.01) compared with control values. These results indicate possible motor-sensory neurotoxicity involving the lower limbs due to long-term metronidazole therapy." @default.
- W90634587 created "2016-06-24" @default.
- W90634587 creator A5016255763 @default.
- W90634587 creator A5028091689 @default.
- W90634587 creator A5029176661 @default.
- W90634587 creator A5044671472 @default.
- W90634587 creator A5047128588 @default.
- W90634587 creator A5071655058 @default.
- W90634587 date "1999-01-01" @default.
- W90634587 modified "2023-09-26" @default.
- W90634587 title "Evaluation of metronidazole toxicity: a prospective study." @default.
- W90634587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10761537" @default.
- W90634587 hasPublicationYear "1999" @default.
- W90634587 type Work @default.
- W90634587 sameAs 90634587 @default.
- W90634587 citedByCount "49" @default.
- W90634587 countsByYear W906345872012 @default.
- W90634587 countsByYear W906345872013 @default.
- W90634587 countsByYear W906345872014 @default.
- W90634587 countsByYear W906345872015 @default.
- W90634587 countsByYear W906345872016 @default.
- W90634587 countsByYear W906345872017 @default.
- W90634587 countsByYear W906345872018 @default.
- W90634587 countsByYear W906345872020 @default.
- W90634587 countsByYear W906345872023 @default.
- W90634587 crossrefType "journal-article" @default.
- W90634587 hasAuthorship W90634587A5016255763 @default.
- W90634587 hasAuthorship W90634587A5028091689 @default.
- W90634587 hasAuthorship W90634587A5029176661 @default.
- W90634587 hasAuthorship W90634587A5044671472 @default.
- W90634587 hasAuthorship W90634587A5047128588 @default.
- W90634587 hasAuthorship W90634587A5071655058 @default.
- W90634587 hasConcept C126322002 @default.
- W90634587 hasConcept C134018914 @default.
- W90634587 hasConcept C141071460 @default.
- W90634587 hasConcept C188816634 @default.
- W90634587 hasConcept C2777396551 @default.
- W90634587 hasConcept C2779901536 @default.
- W90634587 hasConcept C2780852908 @default.
- W90634587 hasConcept C29730261 @default.
- W90634587 hasConcept C42219234 @default.
- W90634587 hasConcept C501593827 @default.
- W90634587 hasConcept C555293320 @default.
- W90634587 hasConcept C71924100 @default.
- W90634587 hasConcept C86803240 @default.
- W90634587 hasConcept C89423630 @default.
- W90634587 hasConcept C90924648 @default.
- W90634587 hasConceptScore W90634587C126322002 @default.
- W90634587 hasConceptScore W90634587C134018914 @default.
- W90634587 hasConceptScore W90634587C141071460 @default.
- W90634587 hasConceptScore W90634587C188816634 @default.
- W90634587 hasConceptScore W90634587C2777396551 @default.
- W90634587 hasConceptScore W90634587C2779901536 @default.
- W90634587 hasConceptScore W90634587C2780852908 @default.
- W90634587 hasConceptScore W90634587C29730261 @default.
- W90634587 hasConceptScore W90634587C42219234 @default.
- W90634587 hasConceptScore W90634587C501593827 @default.
- W90634587 hasConceptScore W90634587C555293320 @default.
- W90634587 hasConceptScore W90634587C71924100 @default.
- W90634587 hasConceptScore W90634587C86803240 @default.
- W90634587 hasConceptScore W90634587C89423630 @default.
- W90634587 hasConceptScore W90634587C90924648 @default.
- W90634587 hasIssue "3" @default.
- W90634587 hasLocation W906345871 @default.
- W90634587 hasOpenAccess W90634587 @default.
- W90634587 hasPrimaryLocation W906345871 @default.
- W90634587 hasRelatedWork W1488793576 @default.
- W90634587 hasRelatedWork W1513961027 @default.
- W90634587 hasRelatedWork W1543985551 @default.
- W90634587 hasRelatedWork W2045402727 @default.
- W90634587 hasRelatedWork W2048201289 @default.
- W90634587 hasRelatedWork W2058255324 @default.
- W90634587 hasRelatedWork W2129398066 @default.
- W90634587 hasRelatedWork W2133023355 @default.
- W90634587 hasRelatedWork W2353188344 @default.
- W90634587 hasRelatedWork W2370935967 @default.
- W90634587 hasVolume "19" @default.
- W90634587 isParatext "false" @default.
- W90634587 isRetracted "false" @default.
- W90634587 magId "90634587" @default.
- W90634587 workType "article" @default.