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- W90663928 abstract "Polyphore 27:10 is a copolymer composed of blocks of polyoxyethylene and polyoxypropylene. Subcutaneous injection of this copolymer in mice causes significant inflammation as determined by footpad swelling and increased vascular permeability as measured by extravasation of Evan's blue dye. Micromolar concentrations trigger release of histamine from purified mouse mast cells and human peripheral blood basophils in vitro. Histamine release from murine mast cells required physiologic temperature, metabolic energy, and calcium ions in the surrounding medium. Replacement of sodium ions in the medium with either potassium or lithium markedly inhibited release. Since Polyphore 27:10 has structural homology with ethylenediamine tetraacetic acid (EDTA) and the crown polyethers, both of which chelate metal ions, The authors investigated whether Polyphore 27:10 could act as an ionophore. The Polyphore transported cations across artificial lipid membranes and made erythrocytes highly permeable to sodium ions, but not calcium at physiologic concentrations. They propose that the potent inflammatory and histamine-releasing activities of this copolymer are in part due to its ability to depolarize and degranulate mast cells." @default.
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- W90663928 date "1986-03-01" @default.
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- W90663928 title "Release of histamine from mast cells by a synthetic ionophore" @default.
- W90663928 hasPublicationYear "1986" @default.
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