Matches in SemOpenAlex for { <https://semopenalex.org/work/W906673544> ?p ?o ?g. }
- W906673544 endingPage "359" @default.
- W906673544 startingPage "341" @default.
- W906673544 abstract "Phagocytosis of pathogens is a primitive, general, effective innate immune mechanism of host defense in mammals that also initiates the highly specific adaptive immune response (1). Phagocytosis as a mechanism of innate immune defense has been appreciated since the late 19th century, when Eli Metchnikov first proposed that mobile phagocytic cells survey tissues for foreign particles and engage in pitched battles with potential pathogens (2). In our current view of the process, we understand that specialized professional phagocytes including macrophages, neutrophils, and dendritic cells seek out invading pathogens and then bind, internalize, kill, and degrade them (1). During this process, phagocytes are stimulated to produce cytokines and chemokines that influence the recruitment and activation of additonal cells of the innate and adaptive immune systems, and they upregulate cell surface molecules required for efficient presentation of antigenic pathogen-derived peptides. For several decades we have understood that particle internalization and the elicitation of inflammatory responses can be uncoupled, leading to the hypothesis that the two systems function independently. With our current understanding of the molecular mechanisms regulating particle internalization and the induction of inflammatory responses, it is now clear that there is much overlap in the molecules utilized for both processes and that there is likely to be crosstalk between the systems." @default.
- W906673544 created "2016-06-24" @default.
- W906673544 creator A5018822912 @default.
- W906673544 date "2003-01-01" @default.
- W906673544 modified "2023-09-23" @default.
- W906673544 title "Innate Immune Signaling During Phagocytosis" @default.
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