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• W90674608 abstract "Reversal of depression in hospitalized bipolar and unipolar endogenously depressed patients treated with imipramine was annulled when they were concomitantly treated with PCPA but not with α-MPT (Shopsin et al., 1975). In another group of hospitalized bipolar and unipolar endogenously depressed patients who showed an antidepressant response to the monoamine oxidase inhibitor, tranylcypromine sulfate, relapse (i.e. depression returned) occurred when relatively small doses of PCPA were added for brief periods (Shopsin et al., 1976). Our collective findings that PCPA similarly reversed the antidepressant effects of both the tricyclic drug, imipramine hydrochloride, and the monoamine oxidase inhibitor tranylcypromine, suggest that (1) serotonergic mechanisms are likely involved in the antidepressant effects of both the tricyclic drugs and MAO inhibitors in man and (2) this indolamine may also play a role in the endogenous clinical state of depression." @default.
• W90674608 created "2016-06-24" @default.
• W90674608 creator A5018548930 @default.
• W90674608 date "1978-01-01" @default.
• W90674608 modified "2023-09-23" @default.
• W90674608 title "A PHARMACOTHERAPEUTIC APPROACH TO RESEARCH INTO DEPRESSIVE ILLNESS" @default.
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• W90674608 doi "https://doi.org/10.1016/b978-1-4832-8322-7.50095-9" @default.
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