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- W90694112 abstract "Abstract Mouse Eri-1 is a 3' to 5' exoribonuclease whose C.elegans counterpart has been shown to inhibit RNAi. We have explored a similar role for murine Eri-1 in T-cells; siRNA efficacy and miRNA levels are increased in Eri-1 deficient T-cells. Reconstitution with wild-type Eri-1 via a retroviral construct returned miRNA levels to their wild-type quantities. In addition to validating a small RNA regulatory role for mouse Eri-1, we are exploring various immunological effects of Eri-1 deficiency. Eri-1 deficient T-cells exhibit an increased propensity to differentiate into Th2 cells in vitro and germinal center formation is altered in the absence of Eri-1." @default.
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- W90694112 date "2009-04-01" @default.
- W90694112 modified "2023-10-16" @default.
- W90694112 title "The role of Eri-1 as a small RNA regulator in the immune system (136.43)" @default.
- W90694112 doi "https://doi.org/10.4049/jimmunol.182.supp.136.43" @default.
- W90694112 hasPublicationYear "2009" @default.
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