FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W90758826> ?p ?o ?g. }

• W90758826 endingPage "9" @default.
• W90758826 startingPage "591" @default.
• W90758826 abstract "The generation of antigen-binding cells (ABC) and plaque-forming cells (PFC) specific for sheep erythrocytes (SRBC) in a primary in vitro response was inhibited by 5-bromo-2′-deoxyuridine (BUdR) present in cultures during the 24 h period immediately preceding harvest. ABC and PFC numbers were greatly reduced by BUdR at a concentration that did not significantly affect cell viability, cell recovery, or the synthesis of total DNA, RNA, or protein, but was sufficient to inhibit the expression of previously unexpressed genes.The effect of BUdR on ABC was seen no earlier than day 3. It lasted through day 6, with maximum inhibition (80–90%) occurring in the day 3–4 interval, coincident with the peak of the ABC response. PFC were inhibited from day 3 to day 5 (the peak of the PFC response), after which time their sensitivity to BUdR was abruptly lost. ABC were inhibited on days 4, 5, and 6, by as little as 0.5 μg/ml, while on any day, PFC were insensitive to concentrations of BUdR below 2.5 μg/ml. A ten-fold molar excess of thymidine blocked the inhibitory effect of the drug.Though maximum inhibition of both T and B ABC numbers by BUdR occurred on day 4, its effect on B cells was greater. BUdR had no effect on the numbers of T and B non-antigen-binding cells.BUdR did not preferentially inhibit surface IgM (sIgM)-bearing ABC though it did prevent the appearance of sIgG receptors on ABC, which normally occurred by day 3, and the loss of sIgD receptors on ABC which was normally complete by day 4. Thus, BUdR decreased the expression of receptors on T ABC as well as B ABC, and prevented the shift in the surface Ig isotypes on B ABC that normally accompanied antigen-driven differentiation." @default.
• W90758826 created "2016-06-24" @default.
• W90758826 creator A5065764297 @default.
• W90758826 creator A5066764918 @default.
• W90758826 date "1979-11-01" @default.
• W90758826 modified "2023-10-18" @default.
• W90758826 title "The requirement for the expression of previously unexpressed genes in the generation of T and B antigen-binding cells and the changes in sIg isotype following in vitro immunization." @default.
• W90758826 cites W1526111415 @default.
• W90758826 cites W1533298047 @default.
• W90758826 cites W1589389703 @default.
• W90758826 cites W1600732437 @default.
• W90758826 cites W1923398670 @default.
• W90758826 cites W1974001218 @default.
• W90758826 cites W1974826215 @default.
• W90758826 cites W1975649472 @default.
• W90758826 cites W197781038 @default.
• W90758826 cites W1978055251 @default.
• W90758826 cites W1980183446 @default.
• W90758826 cites W1981684603 @default.
• W90758826 cites W2025126023 @default.
• W90758826 cites W2048988734 @default.
• W90758826 cites W2056280614 @default.
• W90758826 cites W2079178657 @default.
• W90758826 cites W2084012809 @default.
• W90758826 cites W2085902022 @default.
• W90758826 cites W2086091797 @default.
• W90758826 cites W2091830533 @default.
• W90758826 cites W2092092639 @default.
• W90758826 cites W2097087970 @default.
• W90758826 cites W2097686001 @default.
• W90758826 cites W2099279189 @default.
• W90758826 cites W2109878616 @default.
• W90758826 cites W2133078890 @default.
• W90758826 cites W2151719082 @default.
• W90758826 cites W2153616900 @default.
• W90758826 cites W2924587310 @default.
• W90758826 cites W4247053457 @default.
• W90758826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1457845" @default.
• W90758826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/118113" @default.
• W90758826 hasPublicationYear "1979" @default.
• W90758826 type Work @default.
• W90758826 sameAs 90758826 @default.
• W90758826 citedByCount "0" @default.
• W90758826 crossrefType "journal-article" @default.
• W90758826 hasAuthorship W90758826A5065764297 @default.
• W90758826 hasAuthorship W90758826A5066764918 @default.
• W90758826 hasConcept C147483822 @default.
• W90758826 hasConcept C153911025 @default.
• W90758826 hasConcept C202751555 @default.
• W90758826 hasConcept C203014093 @default.
• W90758826 hasConcept C2777108182 @default.
• W90758826 hasConcept C55493867 @default.
• W90758826 hasConcept C64241487 @default.
• W90758826 hasConcept C86803240 @default.
• W90758826 hasConceptScore W90758826C147483822 @default.
• W90758826 hasConceptScore W90758826C153911025 @default.
• W90758826 hasConceptScore W90758826C202751555 @default.
• W90758826 hasConceptScore W90758826C203014093 @default.
• W90758826 hasConceptScore W90758826C2777108182 @default.
• W90758826 hasConceptScore W90758826C55493867 @default.
• W90758826 hasConceptScore W90758826C64241487 @default.
• W90758826 hasConceptScore W90758826C86803240 @default.
• W90758826 hasIssue "3" @default.
• W90758826 hasLocation W907588261 @default.
• W90758826 hasOpenAccess W90758826 @default.
• W90758826 hasPrimaryLocation W907588261 @default.
• W90758826 hasRelatedWork W131348366 @default.
• W90758826 hasRelatedWork W142719551 @default.
• W90758826 hasRelatedWork W2043084205 @default.
• W90758826 hasRelatedWork W2121437137 @default.
• W90758826 hasRelatedWork W2134386579 @default.
• W90758826 hasRelatedWork W2409441623 @default.
• W90758826 hasRelatedWork W2409878598 @default.
• W90758826 hasRelatedWork W64003601 @default.
• W90758826 hasRelatedWork W80859610 @default.
• W90758826 hasRelatedWork W2077973624 @default.
• W90758826 hasVolume "38" @default.
• W90758826 isParatext "false" @default.
• W90758826 isRetracted "false" @default.
• W90758826 magId "90758826" @default.
• W90758826 workType "article" @default.