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- W907839619 abstract "575 Objectives Primary liver tumors are often evaluated with FDG PET/CT after being detected on contrast-enhanced (CE) CT/MRI. However, many of hepatocellular carcinoma (HCC) are known to exhibit relatively low FDG uptake. The purpose of this study was to review PET/CT findings of primary liver tumors and compare the characteristics with histological results, especially focusing on the difference between HCC and cholangiocellular carcinoma (CCC). Methods This retrospective study reviewed 72 primary liver tumors (one lesion per patient) on FDG PET/CT. They all showed abnormal enhancement suspected as malignant lesions on CE CT/MRI, and histological results were available for all (26 HCCs, 41 CCCs, and 5 others). We evaluated if these tumors were detected visually on PET/CT. In visible tumors, SUVmax was obtained and shape of FDG uptake was classified into focal, inhomogeneous, or ring-like pattern. These PET/CT findings were compared to histological results. Results Twenty-nine (40%) of 72 tumors were not detected visually as abnormal findings on PET/CT. Most (17: 59%) of them were HCCs, while 7 CCCs and 5 others (2 FNHs) were also included. The 17 lesions accounted for 65% of all HCCs. Visible tumors on PET/CT comprised 34 CCCs and 9 HCCs. Mean SUVmax was 7.5+/-4.8 for CCCs and 6.1+/-2.6 for HCCs (no statistical difference). Very strong FDG uptake (SUVmax >10) was observed in 7 (21%) of 34 CCCs, but only in 1 of 9 HCCs. As to shape of FDG uptake, ring-like pattern was demonstrated solely in CCCs, while focal or inhomogeneous pattern was seen both in CCCs and HCCs. Conclusions Although suspected as malignant on CE CT/MRI, 40% of primary liver tumors showed negative findings on PET/CT in this study. HCC (35% sensitivity on PET/CT) was largely responsible for this result, but some of other tumors including CCC also showed negative findings. CCCs appeared to be differentiated from HCCs if showing very strong FDG uptake or ring-like pattern." @default.
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- W907839619 date "2013-05-01" @default.
- W907839619 modified "2023-09-23" @default.
- W907839619 title "Characteristics of FDG uptake on PET/CT in primary liver tumors: Special focus on the difference between HCC and CCC" @default.
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